mProX™ Human MAP4K1 Stable Cell Line

[CAT#: S01YF-1123-KX261]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1166	Magic™ Human HPK1(MAP4K1) in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

MAP4K1

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

MV4-11; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Auditory and Otology Research

Related Diseases

Melnick-Needles Syndrome. Among its related pathways are TGF-Beta Pathway and Angiopoietin-like protein 8 regulatory pathway.

Gene ID

11184

UniProt ID

Q92918

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The MAP4K1 gene in humans encodes the protein kinase known as mitogen-activated protein kinase kinase kinase 1. Another name for it is Hematopoietic Progenitor Kinase 1 (HPK1). It has been demonstrated that the protein contributes to JNK activation. Within the RIG-I-like receptor (RLR) signaling pathway, MAP4K1 functions as a negative regulator. Prior research established that MAP4K1, a member of the Ste20-like serine/threonine kinases, was a key modulator of adaptive immunity through the downregulation of T-cell receptor (TCR) and B-cell receptor (BCR) signaling. Its function in controlling innate immunological signaling against viruses is still unknown, though. The customized MAP4K1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Kathleen

The human MAP4K1 overexpression cell line is easy to work with and consistently provides reliable results. Jan 30 2020

chat Verified Customer

chat Sharon

The MAP4K1 cell line was easy to use, saving me valuable time in the lab. Aug 17 2020

chat Verified Customer

FAQ

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