mProX™ Human MAP3K9 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

MAP3K9, also known as mixed lineage kinase 9, is involved in various biological processes and disease pathways. In the context of thyroid cancer, changes in antioxidant status and DNA repair capacity were found to be associated with molecular alterations in malignant thyroid tissue, and MAP3K9 was found to be one of the mutated genes in both benign thyroid lesions and papillary thyroid cancer (PTC) lesions. This suggests that MAP3K9 may play a role in the transformation of benign thyroid lesions to PTC through the MAPK signaling pathway. In the context of ovarian function, MAP3K9 was identified as a target of microRNA-144-3p, which protects against chemotherapy-induced apoptosis of ovarian granulosa cells and activation of primordial follicles. This suggests that MAP3K9 may be involved in the regulation of ovarian function and could be a potential therapeutic target for preserving ovarian reserve. In the context of honeybee development, low temperature stress during the early pupal stage was found to affect the MAPK signaling pathway, including MAP3K9, as well as pathways related to the nervous system. This suggests that MAP3K9 may contribute to the development and learning ability of adult honeybees. In the context of peri-hilar cholangiocarcinoma, a targetable mutation in MAP3K9 was identified, and pathway analysis revealed its involvement in immunological pathways, including innate and adaptive immune responses. This suggests that MAP3K9 may be a potential target for therapeutic intervention in peri-hilar cholangiocarcinoma. Overall, MAP3K9 has implications in oxidative stress, DNA repair, ovarian function, honeybee development, and cholangiocarcinoma, highlighting its diverse applications in different biological processes and diseases.