mProX™ Human MAP3K4 Stable Cell Line
[CAT#: S01YF-1123-KX294]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
MAP3K4
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
MCF-7; CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Cancer Research
Related Diseases
Breast Neuroendocrine Neoplasm. Among its related pathways are NGF Pathway and NF-KappaB Family Pathway
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The MAP3K4 gene in humans encodes the enzyme mitogen-activated protein kinase kinase 4. A conserved cascade of three protein kinases forms the basic core of every mitogen-activated protein kinase (MAPK) pathway: an active MAPK kinase kinase (MAPKKK) phosphorylates and activates a particular MAPK kinase (MAPKK), which in turn activates a particular MAPK. Environmental pressures activate JNK MAPKs and CSBP2 (p38α) MAPKs, whereas mitogenic stimulation activates ERK MAPKs. The MAPKKK, or MEKK4 protein, also known as MTK1, is encoded by this gene. At the C terminus of this protein lies a protein kinase catalytic domain. A regulatory domain can be present in the N-terminal nonkinase domain. In mammalian cells, MEKK4 expression triggered the JNK MAPK and CSBP2 (p38α) pathways, but not the ERK pathway. The customized MAP3K4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Jason
The results have been consistent and reliable, providing crucial insights into MAP3K4 research.
Mar 21 2020
Verified Customer
Robert
The MAP3K4 KD cell line allowed me to obtain accurate data.
Aug 22 2023
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
