mProX™ Human MAP3K10 Stable Cell Line

[CAT#: S01YF-1023-PY6]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1223	Magic™ Human MLK2(MAP3K10) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;BxPC-3;PANC-1

Target Classification

Kinase Cell Lines

Target Research Area

Cardiovascular Research

Related Diseases

Cardiofaciocutaneous Syndrome 1

Gene ID

Human:4294

UniProt ID

Human:Q02779

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

MAP3K10 has been implicated in various biological processes and diseases. In the field of hypertension and COVID-19, MAP3K10 was identified as one of the top-ranking concepts related to resistant hypertension and COVID-19. In murine cytomegalovirus-induced hearing loss, MAP3K10 was found to be a host restriction factor against viral infection and an upstream regulator of signaling pathways involved in cell death. In intracranial aneurysm, DNA methylation of the MAP3K10 gene was found to be associated with the development of the condition. In pancreatic cancer, miR-146b-3p was found to regulate the proliferation of pancreatic cancer cells with stem cell-like properties by targeting MAP3K10. Additionally, in breast cancer, MAP3K10 was shown to be downregulated by the Hippo tumor suppressor pathway, leading to inhibition of the transcription co-activation and tumor growth mediated by WBP2. Overall, MAP3K10 appears to play a role in various biological processes and diseases, including hypertension, viral infections, aneurysms, and cancer.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Alex Miller (Verified Customer)

How does MAP3K10 interact with miRNAs in cancer? Jan 25 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

Research indicates a reversed nonlinear correlation between MAP3K10 protein levels and miR-146b-3p expression in pancreatic cancer. Jan 25 2021

chat Alex Miller (Verified Customer)

What is the relationship between MAP3K10 and DNA methylation in disease? Jun 12 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

DNA methylation of the MAP3K10 gene may participate in the development of intracranial aneurysm, though the association with MAP3K10 mRNA expression requires further validation. Jun 12 2023

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