mProX™ Human LRRC15 Stable Cell Line

Product Information

Target Family

Other Targets

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;OVCAR-5;OVCAR-7

Target Classification

Other Targets Drug Discovery Assays and Products

Gene ID

Human:131578

UniProt ID

Human:Q8TF66

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

LRRC15, a transmembrane protein, has been studied in various contexts. In the context of SARS-CoV-2, LRRC15 has been found to interact with the receptor binding domain (RBD) of the spike protein, potentially modulating host cell receptiveness for the virus. In mesenchymal stem cells (MSCs), LRRC15 expression is correlated with high levels of stemness regulated by TWIST1, making it a useful marker for estimating stem cell quality in MSCs. In the context of colitis-associated colorectal cancer (CAC), LRRC15 is implicated in the inhibition of epithelial mesenchymal transition and induction of pyroptosis, suggesting its potential as a therapeutic target. Additionally, LRRC15 has been identified as a receptor for SARS-CoV-2 spike protein in fibroblasts, controlling antiviral and antifibrotic transcriptional programs. It is also a marker for a cluster of tumor-promoting cancer-associated fibroblasts (CAFs) called cancer-specific fibroblasts (CSFs), which may play a role in tumor progression.

Protocols

Please visit our protocols page.

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FAQ

chat Jordan Johnson (Verified Customer)

What is the significance of LRRC15 in cancer-associated fibroblasts? May 17 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

LRRC15 is identified as a new marker of cancer-associated fibroblasts and cancers of mesenchymal origin, suggesting its potential as a target for antibody-drug conjugates in tumor stroma. May 17 2023

chat Cameron Jones (Verified Customer)

How does LRRC15 influence osteogenic differentiation? Aug 15 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

LRRC15 plays a crucial role in osteogenesis of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation, indicating its importance in bone regeneration. Aug 15 2023

mProX™ Human LRRC15 Stable Cell Line

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