mProX™ Human LGR6 Stable Cell Line
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- Membrane Protein Stable Cell Lines
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Published Data
Fig.1 Knockdown of LGR6 in colonrectal cancer cell lines.
The inhibition of apoptosis-associated protein expression in colorectal cancer cell lines is achieved through the knockdown of Lgr6. Protein expression in HCT116 and SW480 cells was analyzed by Western blotting.
Ref: Wang, Fei, et al. "Downregulation of Lgr6 inhibits proliferation and invasion and increases apoptosis in human colorectal cancer." International journal of molecular medicine 42.1 (2018): 625-632.
Pubmed: 29693156
DOI: 10.3892/ijmm.2018.3633
Research Highlights
Arman Danielian et al. "Antiaging Effects of Topical Defensins." Facial plastic surgery clinics of North America, 2023
Recent research has focused on the potential of topical defensins to improve skin composition. This study aims to summarize and evaluate existing literature on the impact of topical defensins on skin composition, specifically on their ability to combat signs of aging. A systematic review approach was used to identify and examine relevant studies.
Arman Danielian et al. "Antiaging Effects of Topical Defensins." Facial plastic surgery clinics of North America, 2023
Pubmed:
37806687
DOI:
10.1016/j.fsc.2023.05.010
Yujie Deng et al. "DNA methylation and expression of LGR6 gene in ankylosing spondylitis: A case-control study." Human immunology, 2023
The present research aimed to investigate the relationship between Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 6 (LGR6) methylation and transcript levels with ankylosing spondylitis (AS). Targeted bisulfite sequencing was used to analyze LGR6 DNA methylation in 81 AS cases and 81 controls, while quantitative real-time transcription-polymerase chain reaction (qRT-PCR) was used to measure LGR6 transcription levels in PBMCs from 70 AS cases and 64 controls. Results showed a significant hypomethylation of LGR6 in AS patients (LGR6_1: P = 0.002; LGR6_2: P < 0.001). Additionally, LGR6 transcript levels were significantly decreased in AS (P = 0.001) and were positively correlated with DNA methylation levels (CpG-1: P = 0.010; CpG-2: P = 0.007). The Receiver operating characteristic curve (ROC) demonstrated a good diagnostic performance of LGR6 methylation levels (AUC = 0.676, 95% CI = 0.594-0.758, P < 0.001). Subgroup analysis revealed that gender may influence the methylation pattern of LGR6_1. In conclusion, this study suggests that LGR6 DNA methylation dysregulation may play a role in the development of AS from an epigenetic perspective, potentially leading to the discovery of new biomarkers and treatment options for AS patients.
Yujie Deng et al. "DNA methylation and expression of LGR6 gene in ankylosing spondylitis: A case-control study." Human immunology, 2023
Pubmed:
37802707
DOI:
10.1016/j.humimm.2023.09.005
