mProX™ Human KLRC1 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

KLRC1, also known as NKG2A or CD159A, is a gene that encodes a protein involved in immune response and regulation. Several studies have explored the applications of KLRC1 in different contexts. One study focused on patients who underwent liver transplantation and received immunosuppressive therapy, revealing that CD8+ NKG2A+ natural killer T (NKT) cells specifically expressed KLRC1 and played a crucial role in immune tolerance to liver transplantation. Another study investigated the role of KLRC1 in NK cells and found that it is involved in the regulation of metabolism, thermogenesis, and oxidative phosphorylation in NK cells. Additionally, KLRC1 knockout was shown to improve NK cell antitumor activity against solid tumors by overcoming HLA-E-mediated inhibition. Furthermore, a study in acute myeloid leukemia (AML) patients receiving immunotherapy found that a gene variant of NKG2A (rs1983526) was associated with improved outcome and enhanced NK cell effector function. Lastly, in individuals who did not generate an immune response to the hepatitis B vaccine, KLRC1 expression was found to be significantly higher in CD3highCD16lowKLRG1high NKT cells, suggesting a potential role in the immune response to the vaccine. Overall, these studies highlight the diverse applications of KLRC1 in immune response, transplantation, cancer immunotherapy, and vaccine response.