mProX™ Human KIF5B Stable Cell Line

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;Rat hippocampal neurons

Target Classification

Kinase Cell Lines

Target Research Area

CNS Research

Related Diseases

Skeletal Muscle Disease; Kearns-Sayre Syndrome

Gene ID

Human:3799

UniProt ID

Human:P33176

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

KIF5B is a gene that has been implicated in various types of cancer, including combined large cell neuroendocrine carcinoma (C-LCNEC), non-small cell lung cancer (NSCLC), pulmonary sarcomatoid carcinoma (PSC), and colorectal carcinoma (CRC). In C-LCNEC, KIF5B/RET fusion mutation was detected, and adjuvant chemotherapy with a small cell lung cancer (SCLC) regimen was found to improve disease-free survival and overall survival. In NSCLC, KIF5B-RET fusion was identified as a potential therapeutic target, and treatment with the RET inhibitor pralsetinib showed promising results. In PSC, KIF5B-RET fusion was also detected, and treatment with trametinib was effective. In CRC, RET fusions were found to be a unique molecular subset, and RET fusion-positive CRC may have a higher median tumor mutational burden (TMB) and be commonly microsatellite instability-high (MSI-H). These findings suggest that KIF5B and RET fusions may have important implications for the diagnosis, treatment, and management of these types of cancer.

Protocols

Please visit our protocols page.

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FAQ

chat Taylor Johnson (Verified Customer)

What is the role of KIF5B in pancreatic cancer? Feb 14 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

KIF5B has been identified as a potential biomarker for early pancreatic cancer, particularly in the tumor microenvironment. Feb 14 2021

chat Morgan Brown (Verified Customer)

How does KIF5B mutation affect skeletal development? Sep 19 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

Heterozygous KIF5B variants can cause kyphomelic dysplasia, a specific form of skeletal abnormality. Sep 19 2023

mProX™ Human KIF5B Stable Cell Line

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