mProX™ Human IL2RG Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

IL2RG, also known as interleukin-2 receptor subunit gamma, has various applications in different fields of research. In the field of graft-versus-host disease (GVHD), IL2RG is found to be critical for sustaining T cell responses in target tissues. Its loss leads to aberrant expression of PD-1 in T cells, decreased numbers of tissue-infiltrating PD-1+ T cells, and impaired maintenance of progenitor-like T cells. However, PD-1 blockade can restore the capacity of IL2RG-ablated T cells to mediate GVHD. IL2RG is also required for protecting CD8+ T cells from PD-1 pathway-mediated suppression during GVHD. In the field of ovarian cancer, IL2RG is identified as one of the genes that participate in immune-related molecular mechanisms and regulate the expression of tumor-infiltrating immune cells. It is considered a potential immunotherapy target and prognostic marker for ovarian cancer. In the field of fish immunology, IL2RG is involved in the maturation of the immune system in medaka fish. The interactions between the host immune system and intestinal microorganisms in medaka depend on IL2RG, and reciprocal interactions between the microbiome and the intestinal tract are required for the maturation of the medaka immune system. In the field of periodontitis and alopecia areata, IL2RG is one of the candidate hub immuno-related genes (IRGs) that can be used for diagnosing the co-occurrence of these conditions. IL2RG, along with other hub genes, shows high diagnostic values for identifying patients with both periodontitis and alopecia areata. Finally, in the field of autoimmune rheumatic diseases, IL2RG is discussed in the context of sex bias in immune response. Females generally mount stronger immune responses and are more susceptible to autoimmune rheumatic diseases. IL2RG, located on the X-chromosome, is one of the genes critical for the immune response and may contribute to the sex differences in immune response and disease susceptibility. Overall, IL2RG has implications in GVHD, cancer immunotherapy, fish immunology, co-occurrence of diseases, and understanding sex differences in immune response.