mProX™ Human IL2RA Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

IL2RA, also known as interleukin 2 receptor subunit alpha, has been studied in various medical contexts. In bipolar disorder (BD), IL2RA rs2104286 and IL2 rs2069762 polymorphisms have been found to be associated with the disorder and its clinical features. The study suggests that immuno-inflammatory pathways in the brain and environment contribute to the development of BD. In multiple myeloma (MM), IL2RA rs2104286, IL-2 rs2069762, and rs2069763 polymorphisms have been investigated for their effects on disease susceptibility, progression-free survival (PFS), and overall survival (OS). The study found that the IL2 rs2069762 TG genotype was associated with shorter PFS and OS, while the IL2 rs2069763 GG genotype was associated with shorter PFS. In kidney transplant recipients, the use of lymphocyte-depleting antibodies, such as anti-interleukin-2-receptor antibodies (IL2RA), has been examined in specific populations. The study found that compared to IL2RA, anti-thymocyte globulin (ATG) reduced the risk of acute rejection in standard and high-risk KTR, but did not decrease the risk of graft loss. The optimal induction therapy for kidney transplant recipients is still uncertain and requires further study. In oral cavity squamous cell carcinomas (OSCC), DNA methylation differences within INS, PTPN22, and IL2RA promoters have been observed in lymphocyte subsets. These differences in DNA methylation may contribute to an immunosuppressive tumor microenvironment in OSCC. The study also identified immune-associated long non-coding RNAs (lncRNAs) that may be involved in OSCC. In children with type 1 diabetes (T1D), the effect of T1D-susceptibility associated single nucleotide polymorphism (SNP) markers in INS, PTPN22, and IL2RA on CpG site methylation of their promoters in lymphocyte subsets was investigated. The study found associations between rs689 in INS and methylation at four CpG sites, as well as an association between rs12722495 in IL2RA and methylation at two CpG sites in B cells. These findings suggest that DNA methylation may mediate the genetic effects of these SNPs on T1D pathogenesis. Overall, IL2RA has been studied in the context of bipolar disorder, multiple myeloma, kidney transplantation, oral cavity squamous cell carcinomas, and type 1 diabetes, providing insights into its potential role in these conditions.