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    mProX™ Human IL11RA Stable Cell Line

    [CAT#: S01YF-1023-PY144]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Kinase Cell Lines

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    Host Cell Type:
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    Product Information

    Target Family
    Kinases/Enzyme
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;LO-2
    Target Classification
    Kinase Cell Lines
    Target Research Area
    Orphan Receptor Research
    Related Diseases
    Craniosynostosis And Dental Anomalies; Craniosynostosis
    Gene ID
    Human:3590
    UniProt ID
    Human:Q14626

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    IL11RA, also known as interleukin-11 receptor alpha, is involved in various medical conditions. In craniosynostosis patients, IL11RA is one of the genes with a high diagnostic yield when testing for pathogenic variants. It has been identified as a causative variant in craniosynostosis cases, leading to premature fusion of the skull sutures. IL11RA has also been implicated in ovarian carcinomatosis, where it is expressed in carcinoma-associated mesothelial cells (CAMs) and can be targeted with antibody-drug conjugates for treatment. In hepatic fibrosis, IL-11 derived from hepatic stellate cells promotes hepatocyte injury, suggesting that targeting IL11RA secretion may be a potential therapeutic strategy. Additionally, IL11RA gene expression has been found to be higher in primary melanoma tissues with liver metastasis, indicating its potential role in organ-specific metastasis. Overall, IL11RA has implications in craniosynostosis, ovarian carcinomatosis, hepatic fibrosis, and melanoma liver metastasis.

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    FAQ

    chat Jordan Miller (Verified Customer)

    How is IL11RA related to craniosynostosis syndromes? Apr 22 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    IL11RA mutations are associated with syndromic forms of craniosynostosis, particularly pansynostosis. Apr 22 2022

    chat Alex Smith (Verified Customer)

    What is the significance of IL11RA in cancer research? Jul 19 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Differential expression of IL11RA has been observed in cancers like vulvar carcinoma, suggesting its potential role in cancer development. Jul 19 2020

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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