mProX™ Human IKBKB Stable Cell Line
[CAT#: S01YF-1123-KX264]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
IKBKB
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Immunology Research
Related Diseases
Immunodeficiency 15A and Immunodeficiency 15B. Among its related pathways are MyD88 dependent cascade initiated on endosome and TNFR1 Pathway
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The protein IKK-β, sometimes referred to as inhibitor of nuclear factor kappa-B kinase subunit beta, is encoded by the IKBKB gene in humans. IKK-β is an enzyme that functions as a protein subunit of IκB kinase, a part of the intracellular signaling pathway that is activated by cytokines and responsible for inducing immunological responses. Nuclear Transcription factor kappa-B, or NF-κB, is a transcription factor that is activated by IKK activity. The protein known as the inhibitor of NF-κB, or IκBα, is phosphorylated by activated IKK-β and binds to NF-κB to prevent it from functioning. The ubiquitination pathway breaks down phosphorylated IκB, releasing NF-κB and enabling its entry into the cell nucleus, where it activates several genes linked to inflammation and other immune responses. The customized IKBKB stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
William
The IKBKB KO cell line worked as advertised and was a cost-effective alternative in our studies.
Apr 08 2022
Verified Customer
Jessica
The IKBKB cell line worked flawlessly, and the detailed protocols provided by the company made the whole process much easier.
Aug 10 2022
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
