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  • mProX™ Human ICOS Stable Cell Line

    [CAT#: S01YF-1023-PY181]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Immune Checkpoint Cell Lines

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    Product Information

    Target Family
    Immune Checkpoint
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;Rat T cells
    Target Classification
    Immune Checkpoint Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Immunodeficiency, Common Variable, 1; Common Variable Immunodeficiency
    Gene ID
    Human:29851
    UniProt ID
    Human:Q9Y6W8

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    ICOS (inducible T-cell co-stimulator) has various applications in different fields of research. In a study published in JCI Insight, researchers found that human HLA-DR+CD27+ regulatory T cells have enhanced antigen-specific suppressive function, which could be beneficial for the treatment of autoimmune diseases and graft rejection. Another study published in Prog Urol focused on the profile and immune environment of upper tract urothelial carcinoma. The researchers explored the immune infiltrate of UTUC and the expression of immune checkpoints and co-stimulatory molecules on tumor cells and lymphocytes. In Animal Model Exp Med, the expression and prognosis of ICOS and its ligand in Chinese lung adenocarcinoma patients were investigated. The study found that ICOS/ICOSL might be associated with the prognosis of lung cancer and could be potential therapeutic targets. In Allergy Asthma Clin Immunol, the immunological responses in SARS-CoV-2 and HIV co-infection were compared to SARS-CoV-2 mono-infection. The study highlighted the interplay between the two viruses and its implications for risk-mitigation approaches for HIV-infected individuals. Lastly, in Blood, researchers studied the role of Epstein-Barr virus (EBV) encoded EBNA2 in B-cell lymphoma. They found that EBNA2 downregulates ICOSL by inducing miR-24, which could contribute to immune evasion by EBV in lymphomas. Overall, these studies demonstrate the diverse applications of ICOS in understanding immune responses, cancer immunotherapy, and viral infections.

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    FAQ

    chat Morgan Johnson (Verified Customer)

    What is the significance of ICOS in T cell activation? Nov 17 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ICOS is a critical co-stimulatory molecule that plays a significant role in T cell activation and function. It enhances T cell responses and is involved in the regulation of immune responses, particularly in cancer and autoimmune diseases. Nov 17 2021

    chat Casey Smith (Verified Customer)

    How does ICOS influence cancer immunotherapy? Dec 17 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ICOS has emerged as a potential target in cancer immunotherapy. Its expression on T cells can be indicative of tumor-reactive T cells, and targeting ICOS can enhance the efficacy of immunotherapies, especially in combination with other checkpoint inhibitors like PD-1. Dec 17 2022
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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