mProX™ Human HIPK4 Stable Cell Line

[CAT#: S01YF-1123-KX260]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1165	Magic™ Human HIPK4 in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

HIPK4

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

NIH-3T3; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Adenosquamous Lung Carcinoma

Gene ID

147746

UniProt ID

Q8NE63

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Round spermatids elongate into chromatin-condensed spermatozoa during the amazing biological process known as mammalian spermiogenesis. In mice, spermiogenesis and male fertility depend on homeodomain-interacting protein kinase 4 (HIPK4); the signaling mechanisms that govern this process are poorly understood. HIPK4 is mainly expressed in round and early elongating spermatids, and Hipk4 knockout males are sterile, exhibiting characteristics consistent with oligoasthenoteratozoospermia. Hipk4 mutant sperm have reduced oocyte binding and are incompetent for in vitro fertilization, however they can still produce viable offspring via intracytoplasmic sperm injection. Defects in the filamentous actin (F-actin)-scaffolded acroplaxome during spermatid elongation and aberrant head morphologies in mature spermatozoa are shown by optical and electron microscopy of HIPK4-null male germ cells. The customized HIPK4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat David

The mouse HIPK4 cell line was easy to use, and the customer service team was responsive and helpful. Apr 10 2020

chat Verified Customer

chat David

I am extremely satisfied with this HIPK4 KD cell line and the overall experience. Apr 15 2022

chat Verified Customer

FAQ

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