mProX™ Human HIPK2 Stable Cell Line
[CAT#: S01YF-1123-KX258]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
HIPK2
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
HeLa; CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Cancer Research; Reproductive Research
Related Diseases
Keratoacanthoma and Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations. Among its related pathways are Gene expression (Transcription) and Regulation of TP53 Activity
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The human HIPK2 gene encodes the enzyme homodomain-interacting protein kinase 2. As a serine/threonine protein kinase that interacts with homeodomain transcription factors, HIPK2 falls within this category. It is a member of the DYRK kinases, a family of protein kinases. HIPK2 is present in many different species and is controlled by multiple mechanisms in both apoptosis and gene expression. Through mutations in the speckle retention sequence, abnormal HIPK2 function has been linked to the pathophysiology of disorders such acute myeloid leukemia, myelodysplastic syndrome, and Alzheimer's disease due to HIPK2 hyperdegradation. Kidney fibrosis and cardiovascular disease have also been linked to loss of HIPK2 function, which is consistent with its tissue expression patterns. The customized HIPK2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Linda
The performance of the human HIPK2 cell line was consistent.
Feb 02 2023
Verified Customer
Rebecca
I have tested the HIPK2 KO cell line from Creative Biolabs as one of the most reliable and versatile options available.
Mar 21 2020
Verified Customer
FAQ
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