mProX™ Human HIPK1 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 HIPK1 knockdown reduces tumorigenic activity of A549 lung carcinoma cells.
Cell lines originating from A549 were created and induced to express HIPK1 short hairpin RNA (shRNA). Western blotting was performed after lysing parental A549 cells and A549-derived cell lines (shcontrol, shHIPK1#1 and #2).
Ref: Lee, Deresa, et al. "Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1." EMBO reports 13.2 (2012): 163-169.
Pubmed: 22173032
DOI: 10.1038/embor.2011.235
Research Highlights
It has recently come to light that HIPKs and associated miRNAs play a role in the development of cervical cancer, diabetic nephropathy, gastric cancer chemoresistance, and the expression of recombinant proteins in cultured cells.
Conte, Andrea, and Giovanna M. Pierantoni. "Update on the regulation of HIPK1, HIPK2 and HIPK3 protein kinases by microRNAs." Microrna 7.3 (2018): 178-186.
Pubmed:
29793420
DOI:
10.2174/2211536607666180525102330
Reduced HIPK1 in ALI had protective effects in reducing oxidative stress and inflammation while boosting autophagy, suggesting HIPK1 as a potential target in the treatment of ALI.
Meng, Lan, Xin Zhao, and Hongxia Zhang. "HIPK1 interference attenuates inflammation and oxidative stress of acute lung injury via autophagy." Medical science monitor: international medical journal of experimental and clinical research 25 (2019): 827.
Pubmed:
30734722
DOI:
10.12659/MSM.912507
