mProX™ Human GRK4 Stable Cell Line
[CAT#: S01YF-1123-KX249]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
GRK4
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Cardiovascular Research
Related Diseases
Hypertension, Essential and Hermansky-Pudlak Syndrome 3. Among its related pathways are Visual phototransduction and Myometrial relaxation and contraction pathways
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
Encoded by the GRK4 gene in humans is the enzyme known as G protein-coupled receptor kinase 4 (GRK4). The G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family, which this gene encodes, is primarily related to GRK5 and GRK6. In order to facilitate the binding of an arrestin protein to the receptor, G protein-coupled receptor kinases phosphorylate active G protein-coupled receptors. When an arrestin binds to an active, phosphorylated receptor, heterotrimeric G protein transducer proteins are not stimulated by the receptor, which inhibits cellular communication and causes receptor desensitization. Additionally Receptor signaling via arrestin partner proteins is also made possible by arrestin binding to an active, phosphorylated receptor. Thus, G protein-coupled receptors use the GRK/arrestin system as a signaling switch. The customized GRK4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Richard
The results have been consistent and reliable, providing crucial insights into GRK4 research.
Dec 02 2022
Verified Customer
Timothy
The GRK4 cell line has streamlined my assays and allowed me to obtain accurate data.
Oct 26 2021
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
