mProX™ Human GRK3 Stable Cell Line
[CAT#: S01YF-1123-KX156]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
GRK3
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Digestive and Renal Research; CNS Research
Related Diseases
Whim Syndrome 1 and Bipolar Disorder. Among its related pathways are Vesicle-mediated transport and GPCR downstream signalling
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The human gene ADRBK2 codes for the enzyme G-protein-coupled receptor kinase 3 (GRK3). In order to facilitate the binding of an arrestin protein to the receptor, G protein-coupled receptor kinases phosphorylate active G protein-coupled receptors. By preventing receptor stimulation of heterotrimeric G protein transducer proteins, arrestin binding to phosphorylated, active receptors blocks their cellular signaling and causes receptor desensitization. Additionally, when an arrestin binds to a receptor, the receptor is guided into particular cellular internalization pathways, which eliminates the receptor from the cell surface and stops further activation. Receptor signaling via arrestin partner proteins is also made possible by arrestin binding to phosphorylated, active receptors. Thus, the GRK/arrestin system is the intricate signaling switch of G protein-coupled receptors. The customized GRK3 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Edison
The GRK3 cell line demonstrated remarkable specificity and sensitivity, which helped us unravel complex signaling pathways.
Jun 18 2023
Verified Customer
Pandora
I recently utilized the GRK3 cell line from Creative Biolabs. This cell line proved to be an exceptional targeting tool for my research.
Jan 07 2023
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
