Recommended
Membrane Protein Drug Discovery In Vitro Assays Membrane Protein In Vitro Assay Kits Membrane Protein Stable Cell Lines Membranes Membrane Protein Virus Particles Membrane Staining and Imaging Reagents
  1. Home
  2. GRIK2
  3. mProX™ Human GRIK2 Stable Cell Line
product-img
  • Products
  • Discover MP Targets
  • Discover Research Areas
    • 1- Membrane Protein Stable Cell Line-DiscoverMP Membrane Protein Stable Cell Line, Drug Discovery Tools
    1- Membrane Protein Stable Cell Line-DiscoverMP Other Cell Lines,Drug Discovery Tools

    mProX™ Human GRIK2 Stable Cell Line

    [CAT#: S01YF-1023-PY251]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

    Datasheet MSDS Request COA

    Certificate of Analysis Lookup
    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
    Lot Number

    Bulk Quote

    Made to Order Inquiry

    Inquiry
    Host Cell Type:
    Membrane Protein Engineering:
    Fluorescent Marker:
    Resistance:
    Deliverable:

    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;UM-UC-3
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    CNS Research
    Related Diseases
    Neurodevelopmental Disorder With Impaired Language And Ataxia And With Or Without Seizures; Intellectual Developmental Disorder, Autosomal Recessive 6
    Gene ID
    Human:2898
    UniProt ID
    Human:Q13002

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GRIK2, a gene encoding the kainate receptor subunit GluK2, has been implicated in various neurological disorders. A missense mutation in GRIK2 has been shown to increase dendritic excitability and synaptic integration, leading to altered neuronal function. Additionally, GRIK2 has been associated with the pathogenesis of Parkinson's disease, with the neuroprotective effects of a traditional Chinese formulation mediated through GRIK2-related signaling pathways. In the context of epilepsy, GRIK2 has been identified as a potential target for gene therapy in drug-resistant temporal lobe epilepsy, as downregulating GRIK2 expression reduces seizure activity. Furthermore, interstitial 6q deletions involving GRIK2 have been associated with epilepsy and Prader-Willi-like phenotypes. These findings highlight the diverse applications of GRIK2 in understanding and treating neurological disorders.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human GRIK2 Stable Cell Line (S01YF-1023-PY251). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Cameron Garcia (Verified Customer)

    What is the significance of GRIK2 in neurodevelopmental disorders? Aug 15 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Variants in the GRIK2 gene, which encodes a kainate receptor subunit, are causative for early childhood developmental disorders, emphasizing the importance of clarifying the role of kainate receptors in early nervous system development. Aug 15 2021

    chat Jordan Garcia (Verified Customer)

    How does GRIK2 expression relate to cancer? Jan 20 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GRIK2-derived antigenic peptides are specifically expressed in bladder cancer stem cells, suggesting GRIK2's potential as a target for bladder cancer stem cell-targeting immunotherapy. Jan 20 2023

    Related Products by Target
    • mProX™ Human GRIK2 Stable Cell Line (CAT#: S01YF-1023-PY251)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
    Send Inquiry Send Inquiry
    Inquiry Basket
    compare

    Go to compare