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    mProX™ Human GPR21 Stable Cell Line

    [CAT#: S01YF-1023-PY319]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Orphan Family
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;HepG2
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Gene ID
    Human:2844
    UniProt ID
    Human:Q99679

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GPR21, a G-protein coupled receptor, has been associated with various physiological processes. Recent research has highlighted its potential role in metabolic disorders, inflammation, and immune responses. The modulation of GPR21 activity can influence the inflammatory response, making it a potential therapeutic target for inflammatory diseases.

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    FAQ

    chat Stephanie (Verified Customer)

    How does GPR21 influence glucose uptake in HepG2 cells? Oct 05 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Inhibition of GPR21 can lead to an increase in glucose uptake in HepG2 cells. Specifically, when GPR21 expression is downregulated or when cells are treated with a GPR21-inverse agonist, a significant increase in glucose uptake is observed. Oct 05 2021

    chat Helen (Verified Customer)

    What structural insights are available for GPR21? Sep 14 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Cryo-EM structures have been determined for orphan GPR21 signaling complexes. GPR21 is a class-A orphan G protein-coupled receptor (GPCR) and is a potential therapeutic target for type 2 diabetes and other metabolic disorders. It shows high basal activity in coupling to multiple G proteins even in the absence of any known endogenous agonist or synthetic ligand. Sep 14 2023

    Related Products by Target
    • mProX™ Human GPR21 Stable Cell Line (CAT#: S01YF-1023-PY319)
    • Magic™ Human GPR21 U2OS Cell Line with BLA (Beta-Lactamase) Reporter, Reporter Assay (CAT#: S01YF-1222-KX136)
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