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    mProX™ Human GPR148 Stable Cell Line

    [CAT#: S01YF-1023-PY310]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Orphan Family
    Target Protein Species
    Human
    Host Cell Type
    CHO-K1;HEK293
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Cardiovascular Research;CNS Research
    Related Diseases
    Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome;Autism Spectrum Disorder
    Gene ID
    Human:344561
    UniProt ID
    Human:Q8TDV2

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GPR148, an orphan G protein-coupled receptor, has been the subject of scientific exploration in recent years. Although the specific function and ligands of GPR148 remain to be fully elucidated, emerging research has started to shed light on its potential roles. For instance, GPR148 has been implicated in the regulation of myelination and remyelination processes. Specifically, GPR148 is enriched in oligodendrocyte precursor cells (OPCs) and has been shown to negatively regulate the differentiation of OPCs to oligodendrocytes, as well as myelination and remyelination. This suggests that targeting GPR148 might offer therapeutic avenues for promoting myelin repair in demyelinating diseases. Furthermore, GPR148 has been associated with diabetic nephropathy, indicating its potential involvement in kidney-related pathologies. As research continues, the understanding of GPR148's role in various physiological and pathological processes is expected to expand.

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    FAQ

    chat Sarah (Verified Customer)

    How is GPR148 related to the GPCR Class A Rhodopsin receptors? Jul 24 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR148 is a member of the GPCR Class A Rhodopsin receptors. Phylogenetic studies based on sequence-structure have been conducted to understand the evolutionary relationships and potential ligand associations for these receptors. Jul 24 2020

    chat Kevin (Verified Customer)

    Are there any genetic variations involving GPR148 that may have clinical implications? Oct 10 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, small rare recurrent deletions and reciprocal duplications in the 2q21.1 region, which includes GPR148 and the brain-specific ARHGEF4, have been identified. These genetic variations may have potential implications in neurological disorders. Oct 10 2022

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    • mProX™ Human GPR148 Stable Cell Line (CAT#: S01YF-1023-PY310)
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