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    mProX™ Human GPR146 Stable Cell Line

    [CAT#: S01YF-1023-PY309]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Orphan Family
    Target Protein Species
    Human
    Host Cell Type
    KATO;III;CHO-K1;HEK293
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Gene ID
    Human:115330
    UniProt ID
    Human:Q96CH1

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GPR146, a G Protein-Coupled Receptor, has recently been associated with cholesterol metabolism. Studies have shown that hypercholesterolemia risk-associated GPR146 regulates blood cholesterol levels in both humans and mice. Furthermore, GPR146 variants have been linked to a beneficial cardiometabolic risk profile, suggesting its potential as a therapeutic target for atherosclerosis and related conditions. The emerging research on GPR146 underscores its significance in maintaining cholesterol homeostasis and its potential implications for cardiovascular health.

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    FAQ

    chat Melissa (Verified Customer)

    How does GPR146 deficiency impact hypercholesterolemia and atherosclerosis? Apr 29 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR146 deficiency has been shown to provide protection against hypercholesterolemia and atherosclerosis. Remarkably, GPR146-deficient mice exhibited reduced plasma cholesterol levels and a significant decrease in aortic atherosclerotic lesions. Apr 29 2021

    chat Ronald (Verified Customer)

    Is GPR146 a potential therapeutic target for cholesterol homeostasis? Aug 29 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, GPR146 has emerged as a potential therapeutic target for achieving cholesterol homeostasis. Genome-wide association studies have linked GPR146 to human atherosclerosis, and its influence on serum cholesterol homeostasis has been described in recent research. Aug 29 2022

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    • mProX™ Human GPR146 Stable Cell Line (CAT#: S01YF-1023-PY309)
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