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    mProX™ Human GPR139 Stable Cell Line

    [CAT#: S01YF-1023-PY305]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Orphan Family
    Target Protein Species
    Human
    Host Cell Type
    CHO-K1;HEK293
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    CNS Research;Metabolic Research
    Related Diseases
    Adult-Onset Severe Asthma;Isolated Growth Hormone Deficiency, Type Ib
    Gene ID
    Human:124274
    UniProt ID
    Human:Q6DWJ6

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GPR139 is a neuromodulatory orphan receptor that has been associated with various neuropsychiatric behaviors. Recent studies have shown that loss of GPR139 in mice results in neuropsychiatric manifestations, including increased anxiety-related traits and social interaction deficits, suggesting schizophrenia-like symptoms. Moreover, GPR139 has been linked to the regulation of body mass, blood glucose, and insulin, indicating its potential role in metabolic disorders. The recent discovery of TAK-041, a potent and selective GPR139 agonist, has further highlighted the therapeutic potential of targeting GPR139 for the treatment of negative symptoms associated with schizophrenia.

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    FAQ

    chat Ronald (Verified Customer)

    How is GPR139 associated with fear learning in zebrafish? Nov 18 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR139 is an evolutionarily conserved orphan receptor predominantly expressed in the habenula of vertebrate species. Research suggests that activation of GPR139 signaling in the habenula may be involved in fear learning processes in zebrafish. Nov 18 2021

    chat Paul (Verified Customer)

    What is the significance of the orphan GPR139 G protein-coupled receptor? Jul 24 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR139 is an orphan G protein-coupled receptor. While its endogenous agonists are not firmly established, aromatic amino acids L-Trp and L-Phe have been shown to activate it. This receptor has potential implications in metabolic disorders and Parkinson's disease. Jul 24 2020

    Related Products by Target
    • mProX™ Human GPR139 Stable Cell Line (CAT#: S01YF-1023-PY305)
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