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    mProX™ Human GPR137B Stable Cell Line

    [CAT#: S01YF-1023-PY304]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
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    Product Information

    Target Family
    Orphan Family
    Target Protein Species
    Human
    Host Cell Type
    Hs68;CHO-K1;HEK293
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    CNS Research;Metabolic Research
    Related Diseases
    Retinitis Pigmentosa 60;Ceroid Lipofuscinosis, Neuronal, 1
    Gene ID
    Human:7107
    UniProt ID
    Human:O60478

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GPR137B is another orphan G-protein coupled receptor that has garnered attention in the scientific community. Recent studies have highlighted its role in modulating hepatic stellate cell activation, which is crucial in the pathogenesis of liver fibrosis. Additionally, GPR137B has been identified as a lysosomal protein that regulates the localization and activity of mTORC1, a key player in cell growth and metabolism. Furthermore, GPR137B has been associated with M2 macrophage polarization, suggesting its potential involvement in immune responses.

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    FAQ

    chat Kimberly (Verified Customer)

    How does the lncRNA Gpr137b-ps relate to hepatic stellate cell (HSC) activation? Nov 09 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    The lncRNA Gpr137b-ps, in conjunction with miR-200a-3p and CXCL14, plays a role in modulating hepatic stellate cell (HSC) activation. Silencing of lncRNA Gpr137b-ps or CXCL14 can improve fibrotic changes in the liver. Nov 09 2021

    chat Jennifer (Verified Customer)

    What is the association of GPR137B with macrophage polarization? Apr 19 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR137B is an orphan G-protein-coupled receptor that is associated with M2 macrophage polarization. This suggests a potential role of GPR137B in immune responses and inflammation regulation. Apr 19 2022

    Related Products by Target
    • mProX™ Human GPR137B Stable Cell Line (CAT#: S01YF-1023-PY304)
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