mProX™ Human FYN Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1151	Magic™ Human FYN[isoforma] in Vitro Assay	Human		Kinase Assay
S01YF-1122-KX1152	Magic™ Human FYN[isoformb] in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

FYN

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

MDA-MB-231; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Infectious Research; CNS Research

Related Diseases

Hepatitis E and Prion Disease. Among its related pathways are EPH-Ephrin signaling and CD28 co-stimulation

Gene ID

2534

UniProt ID

P06241

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Tyrosine-protein kinase, a proto-oncogene The FYN gene in humans codes for the enzyme fyn. Fyn is a 59-kDa member of the Src family of kinases that is normally linked to proper cell physiology and T-cell and neural communication during development. Numerous malignancies can arise as a result of disturbances in various signaling pathways. The proteins that Fyn codes for aid in controlling cell division. It becomes an oncogene due to mutations in its DNA sequence, which affects how normal cell regulation functions and causes the synthesis of an alternative protein. The protein-tyrosine kinase oncogene family includes the oncogene Fyn. The protein interacts with the fyn-binding protein and forms an association with the p85 subunit of phosphatidylinositol 3-kinase. The customized FYN stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat William

This FYN cell line is essential for our study. Applications of this cell line can be developed through more innovation and customisation of the protocol. May 06 2020

chat Verified Customer

chat John

I choose the FYN cell line with luminescent signals. This makes my testing steps less complicated. Nov 15 2020

chat Verified Customer

FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 FYN induces EMT in breast cancer cells.

Vimentin and E-cadherin expression, as well as the distribution and shape of F-actin, were examined using immunofluorescence in FYN-transfected MCF10A and FYN-depleted MDA-MB-231 cells.

Ref: Xie, Ye-Gong, et al. "FYN promotes breast cancer progression through epithelial-mesenchymal transition." Oncology reports 36.2 (2016): 1000-1006.

Pubmed: 27349276

DOI: 10.3892/or.2016.4894

Research Highlights

Comprehending Fyn's function in the onset, advancement, and resistance to anti-cancer therapeutic agents can aid in the creation and application of innovative medications that specifically target Fyn, so improving the management of cancers.
Elias, Daniel, and Henrik J. Ditzel. "Fyn is an important molecule in cancer pathogenesis and drug resistance." Pharmacological research 100 (2015): 250-254.
Pubmed: 26305432 DOI: 10.1016/j.phrs.2015.08.010

Fyn is a cytoplasmic tyrosine kinase (TK) that is non-receptor and a member of the Src family of kinases (SFKs). It is involved in several transduction pathways in the central nervous system (CNS), such as oligodendrocyte development, myelination, axon guidance, and synaptic transmission.
Matrone, Carmela, et al. "Fyn tyrosine kinase as harmonizing factor in neuronal functions and dysfunctions." International journal of molecular sciences 21.12 (2020): 4444.
Pubmed: 32580508 DOI: 10.3390/ijms21124444