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    mProX™ Human FGL1 Stable Cell Line

    [CAT#: S01YF-1023-PY269]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;PC-9
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Cancer Research
    Related Diseases
    Hepatocellular Carcinoma; Lung Cancer
    Gene ID
    Human:2267
    UniProt ID
    Human:Q08830

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    FGL1, or fibrinogen-like protein 1, has been found to play a role in immune escape and progression of metastatic colorectal cancer. It is secreted by cancer cells and hepatocytes and reduces the infiltration of T cells. FGL1 stability is enhanced by the TAM-OTUD1-FGL1 axis, which is activated by tumor-associated macrophages (TAMs) in the liver microenvironment. Disrupting this axis inhibits tumor progression and synergizes with immune checkpoint blockade therapy. High plasma FGL1 levels predict poor outcomes and reduced benefits from immunotherapy. Additionally, FGL1 has been found to be highly expressed in head and neck squamous cell carcinoma (HNSCC) and promotes the malignant progression of HNSCC cells. In non-small cell lung cancer (NSCLC), various chemotherapeutic drugs have been shown to upregulate the expression of immune checkpoint ligands, including PD-L1 and PD-L2, which may impact the efficacy of combined immunotherapy.

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    There are currently no Customer reviews or questions for mProX™ Human FGL1 Stable Cell Line (S01YF-1023-PY269). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Morgan Jones (Verified Customer)

    How does FGL1 interact with the immune system in cancer? Jun 10 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    FGL1 plays a role in tumor epithelial to mesenchymal transition and immune escape, suggesting its involvement in modulating the immune response in cancer. Jun 10 2023

    chat Peyton Johnson (Verified Customer)

    Can FGL1 be used as a diagnostic marker for hepatocellular carcinoma? Nov 01 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Serum FGL1 levels are significantly elevated in patients with HBV-related hepatocellular carcinoma, indicating its potential as a diagnostic marker. Nov 01 2022

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