mProX™ Human FCGRT Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Fc Receptor Cell Lines
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Published Data
Fig.1 Silence of FCGRT in U25l reduced the malignant progression of glioma cells.
The assay for colony formation was conducted and quantified subsequent to the transfection of U25l cells with siCtl or si-FCGRT.
Ref: Yang, Gaoshan, et al. "FCGRT, a cancer-derived immunoglobulin G binding protein, mediates the malignant phenotype of glioma." bioRxiv (2022): 2022-12.
Pubmed: NA
DOI: NA
Research Highlights
Pannek, Andreas. et al. "The endosomal system of primary human vascular endothelial cells and albumin-FcRn trafficking." Journal of cell science, 2023.
In the study, the researchers aimed to investigate the trafficking of FcRn-albumin complexes in primary human endothelial cells. The authors generated primary human vascular endothelial cell lines, known as blood outgrowth endothelial cells (BOECs), from blood endothelial precursors. They mapped the endosomal system in BOECs and observed that fluorescently labelled HSA was efficiently internalised primarily through fluid-phase macropinocytosis. The study also showed that HSA molecules co-localised with FcRn in acidic endosomal structures and that wildtype HSA, but not the non-FcRn-binding HSAH464Q mutant, was excluded from late endosomes and/or lysosomes. Live imaging revealed that FcRn-positive tubules derived from maturing macropinosomes transport HSA towards the plasma membrane. These findings provide insights into the FcRn-albumin trafficking pathway in primary vascular endothelial cells, with implications for albumin homeostasis.
Pannek, Andreas. et al. "The endosomal system of primary human vascular endothelial cells and albumin-FcRn trafficking." Journal of cell science, 2023.
Pubmed:
37565427
DOI:
10.1242/jcs.260912
Ji, Yuekai. et al. "Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels." Arteriosclerosis, thrombosis, and vascular biology, 2023.
The natural anticoagulant proteins antithrombin, PC (protein C), and PS (protein S) play a crucial role in regulating hemostasis and have been linked to venous thromboembolism when their levels are partially deficient. However, previous genetic association studies investigating these proteins were hindered by small sample sizes or limited to specific genes. Through a collaboration with the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, 10 genome-wide association studies were conducted across different ancestries to meta-analyze the results of plasma levels of these proteins.
Ji, Yuekai. et al. "Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels." Arteriosclerosis, thrombosis, and vascular biology, 2023.
Pubmed:
37128921
DOI:
10.1161/ATVBAHA.122.318213
