mProX™ Human FCGRT Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The FCGRT gene, which encodes the neonatal Fc receptor (FcRn), has been studied in various contexts. In primary human vascular endothelial cells, FcRn is involved in the trafficking of albumin, contributing to albumin homeostasis. FcRn-albumin complexes are internalized and transported in acidic endosomal structures, and wildtype albumin is excluded from late endosomes and/or lysosomes. FcRn-positive tubules derived from maturing macropinosomes transport albumin towards the plasma membrane. In the context of antithrombin, protein C, and protein S, genome-wide association studies have identified novel loci regulating plasma levels of these proteins. One of these loci is the FCGRT gene, which is associated with antithrombin levels. Additionally, epigenetic control of CD1D expression, a gene involved in antigen presentation, has been identified as a mechanism of resistance to immune checkpoint therapy in melanomas. FCGRT is one of the genes found to be associated with CD1D expression. Finally, in neonatal buffalo calves, genetic variation in the FCGRT gene is associated with serum IgG levels, potentially impacting the transfer of passive immunity. Overall, FCGRT plays a role in albumin homeostasis, plasma protein regulation, immune checkpoint therapy resistance, antigen presentation, and passive immunity transfer.