mProX™ Human FCGR1BP Stable Cell Line

Product Information

Target Family

Fc Receptor

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;SEM

Target Classification

Fc Receptor Cell Lines

Target Research Area

Cancer Research;CNS Research

Related Diseases

Cerebral Neuroblastoma

Gene ID

Human:2210

UniProt ID

Human:#N/A

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

FCGR1BP, also known as Fc gamma receptor 1 binding protein, has been found to play a crucial role in various biological processes. In one study, it was demonstrated that FCGR1BP is involved in the regulation of immune responses, particularly in the activation of natural killer cells and macrophages. Another study highlighted its significance in the clearance of immune complexes, suggesting its potential as a therapeutic target for autoimmune diseases. Additionally, FCGR1BP has been implicated in the pathogenesis of certain cancers, with its overexpression being associated with tumor progression and poor prognosis. Overall, these findings suggest that FCGR1BP has diverse applications in immunology and oncology, making it a promising candidate for further research and potential therapeutic interventions.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Casey Johnson (Verified Customer)

How can FCGR1BP-overexpression cell lines be utilized in research? Apr 09 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

These cell lines can be instrumental in immunological research, particularly in understanding the mechanisms of antibody-mediated immune responses. They can also be used to explore the potential therapeutic targets for diseases where the immune system plays a critical role, such as autoimmune disorders and certain types of cancers. Apr 09 2021

chat Morgan Smith (Verified Customer)

Are there any known risks associated with using FCGR1BP-overexpression cell lines? Jun 15 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

As with any genetically modified cell line, there is a need for careful handling and containment to prevent unintended release into the environment. Additionally, the overexpression of immune-related proteins like FCGR1BP could potentially lead to altered cellular behavior, which needs to be carefully monitored and controlled during experiments. Jun 15 2021

Published Data

Fig.1 Exploring the Influence of FCGR1B on Prednisolone Resistance in MLL-Rearranged Infant Acute Lymphoblastic Leukemia (ALL) Cell Culture Models

Ref: Spijkers-Hagelstein, J. A. P., et al. "Chemical genomic screening identifies LY294002 as a modulator of glucocorticoid resistance in MLL-rearranged infant ALL." Leukemia 28.4 (2014): 761-769.

Pubmed: 23958920

DOI: 10.1038/leu.2013.245