mProX™ Human FCGR1A Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Fc Receptor Cell Lines
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Patrick Liam (Creative Biolabs Scientific Support)
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Patrick Liam (Creative Biolabs Scientific Support)
Published Data
Fig.1 The promotion of ovarian cancer cell proliferation by FCGR1A was observed, with a notable impact on cellular growth rates.
Quantification was performed on CCK8 assays conducted with shctrl and shFCGR1A SKOV3 cells, encompassing a total of three replications. The findings unveiled a noteworthy decline in the growth of ovarian cancer (OC) cells as a direct consequence of FCGR1A knockdown.
Ref: Jiang, Hui, et al. "CRISPR/Cas9-based genome-wide screening for Metastasis ability identifies FCGR1A regulating the metastatic process of ovarian cancer by targeting LSP1." (2023).
Pubmed: NA
DOI: NA
Research Highlights
Mutua, Florence. et al. "Type I interferons and Mycobacterium tuberculosis whole cell lysate induce distinct transcriptional responses in M. tuberculosis infection." Tuberculosis (Edinburgh, Scotland), 2023.
Type I interferon (IFN)-induced genes exhibit promise in distinguishing active tuberculosis (ATB) from latent TB infection (LTBI) and healthy controls (HC), tracking treatment progress, and identifying individuals at risk of progressing to active disease. Researchers investigated the distinct impacts of IFN-α, IFN-β, and Mycobacterium tuberculosis whole cell lysate (Mtb WCL) stimulation on specific IFN-stimulated genes in peripheral blood mononuclear cells from individuals with LTBI, ATB, and HC. IFN-α and IFN-β stimulation led to increased gene expression, whereas Mtb WCL stimulation mostly maintained baseline levels, except for IL-1A and IL-1B genes, which were downregulated. Differential expression of specific genes in response to these stimuli showed promise in distinguishing between LTBI and ATB, suggesting potential for further mechanistic exploration and host-directed therapeutic strategies.
Mutua, Florence. et al. "Type I interferons and Mycobacterium tuberculosis whole cell lysate induce distinct transcriptional responses in M. tuberculosis infection." Tuberculosis (Edinburgh, Scotland), 2023.
Pubmed:
37729851
DOI:
10.1016/j.tube.2023.102409
F Theeuwes, Wessel. et al. "CD64 as novel molecular imaging marker for the characterization of synovitis in rheumatoid arthritis." Arthritis research & therapy, 2023.
Rheumatoid arthritis (RA) is a common and severe form of joint disease observed globally. Its main feature is inflammation of the synovial membrane (synovitis), which is closely associated with joint damage. To determine the presence and severity of synovitis, magnetic resonance imaging and ultrasonography are commonly utilized. Nonetheless, these diagnostic methods do not provide information on the activation status of certain inflammatory cells, particularly macrophages, which express the Fc gamma receptor CD64 and are known to play a significant role in synovitis.
F Theeuwes, Wessel. et al. "CD64 as novel molecular imaging marker for the characterization of synovitis in rheumatoid arthritis." Arthritis research & therapy, 2023.
Pubmed:
37653557
DOI:
10.1186/s13075-023-03147-y
