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  • mProX™ Human F3 Stable Cell Line

    [CAT#: S01YF-1023-PY267]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;HK-1;AGS
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Immunology Research
    Related Diseases
    Disseminated Intravascular Coagulation; Carotid Artery Thrombosis
    Gene ID
    Human:2152
    UniProt ID
    Human:P13726

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    F3, commonly known as Tissue Factor (TF), is a cell surface glycoprotein that plays a crucial role in the initiation of the blood coagulation cascade. Beyond its hemostatic functions, F3 has been implicated in various pathological processes, including tumor growth, angiogenesis, and metastasis. The overexpression of F3 in many cancers has led researchers to explore its potential as a therapeutic target. Its involvement in tumor-associated thrombosis and its role in promoting tumor cell migration and invasion underline its significance in oncology research.

    Protocols

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    FAQ

    chat Taylor Williams (Verified Customer)

    How does F3-mediated platelet aggregation affect antitumor natural killer cells? Jun 23 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    EBV infection induces F3-mediated platelet aggregation, which inhibits the antitumor function of natural killer (NK) cells. This provides a rationale for developing therapies combining NK cell-based treatments with F3 inhibitors for EBV-associated epithelial malignancies. Jun 23 2023

    chat Peyton Williams (Verified Customer)

    What is the impact of F3 on the gut microbiota in mice? Nov 27 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Different fractions of whey protein hydrolysate treated by electrodialysis, including F3, showed changes in the gut microbiota composition and functions in mice, suggesting potential health impacts. Nov 27 2022
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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