mProX™ Human EPHA6 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 Knock-down of EphA6 decreases tumor angiogenesis
Formation of human endothelium cell tubes. After being plated onto Matrigel for 24 hours, human microvessel endothelial cells were treated with 30% conditioned media from PC-3M/shEphA6-2, PC-3M/shEphA6-3, or PC-3M/shControl cells.
Ref: Li, Shibao, et al. "EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression." Oncotarget 6.26 (2015): 22587.
Pubmed: 26041887
DOI: 10.18632/oncotarget.4088
Research Highlights
These results show that EphA6 is a unique metastatic gene that positively correlates with the progression of CaP. In cases of metastatic CaP, ephA6 might be a therapeutic target.
Li, Shibao, et al. "EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression." Oncotarget 6.26 (2015): 22587.
Pubmed:
26041887
DOI:
10.18632/oncotarget.4088
A multifunctional nuclear protein involved in RNA splicing, processing, and transcriptional regulation of nuclear hormone receptors is p54nrb/NONO, an octamer binding protein that lacks a POU domain.
Yamamoto, Ryuji, et al. "Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth." Oncotarget 9.12 (2018): 10510.
Pubmed:
29535823
DOI:
10.18632/oncotarget.24063
