mProX™ Human EPHA1 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1122	Magic™ Human EPHA1 in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

EPHA1

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

DLD1; HCT116; HT29; SW480; SW620; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research; Reproductive Research

Related Diseases

Craniofrontonasal Syndrome and Liver Carcinoma In Situ. Among its related pathways are GPCR Pathway and ERK Signaling

Gene ID

2041

UniProt ID

P21709

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The EPHA1 gene in humans encodes the protein known as EPH receptor A1 (ephrin type-A receptor 1). This gene is a member of the protein-tyrosine kinase family's ephrin receptor subfamily. Developmental events have been linked to EPH and EPH-related receptors, especially in the nervous system. The extracellular region of receptors in the EPH subfamily usually has two repeats of fibronectin type III and a Cys-rich domain, in addition to a single kinase domain. Based on the similarity of their extracellular domain sequences and their propensity to bind ephrin-A and ephrin-B ligands, the ephrin receptors are classified into two classes. This gene has been linked to carcinogenesis and is expressed in some human cancer cell lines. The customized EPHA1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Linda

The EPHA1 cell line is a good product for general routine use from Creative Biolabs. Jul 24 2023

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chat Karen

I recently purchased the EPHA1 cell line, and it has been a valuable tool in my laboratory work. Jun 04 2022

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 Expression of EphA1 in colon cancer cell lines.

The expression of the EphA1 transcript in the colon cancer cell lines DLD1, HT29, HCT116, SW480, and SW620 was determined by RT-PCR. All of the colon cancer cell lines had EphA1 mRNA.

Ref: Dong, Yingchun, et al. "Downregulation of EphA1 in colorectal carcinomas correlates with invasion and metastasis." Modern Pathology 22.1 (2009): 151-160.

Pubmed: 19011600

DOI: 10.1038/modpathol.2008.188

Research Highlights

The findings indicate that the rs11767557 mutation may be able to substantially control the expression of the EPHA1 gene in human whole blood. These results may also offer significant additional information regarding the rs11767557 variant's regulatory mechanisms in relation to AD risk.
Liu, Guiyou, et al. "Alzheimer's disease rs11767557 variant regulates EPHA1 gene expression specifically in human whole blood." Journal of Alzheimer's Disease 61.3 (2018): 1077-1088.
Pubmed: 29332039 DOI: 10.3233/JAD-170468

RTK EphA1 is a valuable therapeutic target for novel anti-tumor therapeutics, a biomarker for tumor diagnosis (particularly as a prognostic sign), and a new anti-tumor medication.
Wu, Yinxin, et al. "The Functions of EphA1 Receptor Tyrosine Kinase in Several Tumors." Current Medicinal Chemistry 30.20 (2023): 2340-2353.
Pubmed: 35996244 DOI: 10.2174/0929867329666220820125638