mProX™ Human EML4 Stable Cell Line
[CAT#: S01YF-1123-KX223]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
EML4
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
HeLa; CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Cancer Research
Related Diseases
Lymphoma and Lung Cancer. Among its related pathways are Signaling by ALK in cancer and "Cell Cycle, Mitotic"
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The human EML4 gene encodes a protein known as echinoderm microtubule-associated protein-like 4. The splicing of this protein with anaplastic lymphoma kinase results in its involvement in malignancies. The ALK-EML4 fusion links the ALK gene to "echinoderm microtubule associated protein-like 4" (EML4), a gene involved in microtubule production and stabilization. A transforming fusion tyrosine kinase is produced by this fusion, and lung tumors have been found to express many isoforms of this enzyme. ALK and EML4 are oppositely orientated and situated on the short arm of chromosome 2, separated by a distance of 12 megabases (Mb) in sequence. Over nine distinct variations of the EML4-ALK fusion have been discovered thus far. The customized EML4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
John
This EML4 cell line is the best choice for laboratories wishing to minimise troubleshooting time and maximise data and experimental volumes.
Dec 25 2022
Verified Customer
Stephanie
The ideal EML4 cell line, often used in our laboratories.
Jul 10 2022
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
