mProX™ Human DYRK4 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1108	Magic™ Human DYRK4 in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

DYRK4

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Metabolic Research; Reproductive Research

Related Diseases

Intellectual Developmental Disorder, Autosomal Dominant 7 and Abdominal Obesity-Metabolic Syndrome 3

Gene ID

8798

UniProt ID

Q9NR20

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4, or DYRK4, is crucial for the growth, survival, and multiplication of cells. According to Northern Blot research, DYRK4 expression in the testis is highly confined to stage VIII postmeiotic spermatids. A DYRK4 defective mouse line's analysis revealed that DYRK4 is not necessary for male fertility, indicating that some DYRK isoforms have redundant functions during spermiogenesis. The N-terminal half of the DYRK4 protein has a DYRK homology box, which is followed by a central kinase domain with a YxY loop. The customized DYRK4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Emily

I recently had the opportunity to try the DYRK4 cell line from Creative Biolabs, and I am quite impressed. The product arrived promptly, and the packaging was secure. Mar 27 2022

chat Verified Customer

chat Elizabeth

I can't speak highly enough about the DYRK4 cell line. It has exceeded my expectations in terms of performance and has become an invaluable asset in our lab. Nov 25 2020

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 DYRK gene NB tumor mRNA expression and prognostic significance.

The DYRK gene family's mRNA expression was examined in SEQC-498, the most publicly available genome-wide RNA sequencing dataset on human NB tumors. Bar chart showing the tumor mRNA expression of the DYRK gene in the SEQC-498 patient group.

Ref: Uhl, Katie L., et al. "Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma." Cancer cell international 18.1 (2018): 1-14.

Pubmed: 29977157

DOI: 10.1186/s12935-018-0574-3

Research Highlights

This finding provides insights into a novel aspect of the molecular pathobiology of luminal B cancers and suggests new avenues for the treatment of more aggressive breast tumors that overexpress this fusion.
Liu, Chia-Chia, et al. "A novel neoplastic fusion transcript, RAD51AP1-DYRK4, confers sensitivity to the MEK inhibitor trametinib in aggressive breast cancers." Clinical Cancer Research 27.3 (2021): 785-798.
Pubmed: 33172895 DOI: 10.1158/1078-0432.CCR-20-2769

The study found a link between peripheral blood DYRK4 hypomethylation and LC, indicating that blood-based DNA methylation may be a viable novel biomarker for LC detection.
Qiao, Rong, et al. "Hypomethylation of DYRK4 in peripheral blood is associated with increased lung cancer risk." Molecular Carcinogenesis (2023).
Pubmed: 37530470 DOI: 10.1002/mc.23612