mProX™ Human DYRK1A Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1104	Magic™ Human DYRK1A in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

DYRK1A

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Reproductive Research

Related Diseases

Intellectual Developmental Disorder, Autosomal Dominant 7 and Dyrk1a-Related Intellectual Disability Syndrome. Among its related pathways are "Cell Cycle, Mitotic" and Mitotic G1 phase and G1/S transition

Gene ID

1859

UniProt ID

Q13627

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Instructions for producing an enzyme crucial to the nervous system's development are provided by the DYRK1A gene. The DYRK1A enzyme is a kinase, which means that it phosphorylates other proteins by adding a cluster of atoms containing phosphorus and oxygen. The proteins that the DYRK1A enzyme aids in regulating are involved in a number of cellular activities. The DYRK1A enzyme is involved in the development of dendritic spines from dendrites in nerve cells. The transmission of nerve impulses depends on dendrites, which are specialized extensions from neurons. Small projections from dendrites called dendritic spines aid in nerve impulse transmission and improve neuronal communication. The customized DYRK1A stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Karen

I am truly impressed with the performance of this DYRK1A cell line and the professionalism of Creative Biolabs. I highly recommend it to anyone. Mar 15 2022

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chat Christopher

I purchased the DYRK1A cell line from Creative Biolabs. The provided documentation was comprehensive and helped me optimize my assay conditions. Jan 03 2020

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 DYRK1A co-purifies with p300 and CBP.

After creating a clonal HEK293 cell line that inducibly expressed Flag-DYRK1A, nuclear extracts were produced and then affinity purified. Mass spectrometry and SDS-PAGE were used to analyze the luates. The position of DYRK1A in the silver-stained gel is shown by an arrow.

Ref: Li, Shanshan, et al. "DYRK1A interacts with histone acetyl transferase p300 and CBP and localizes to enhancers." Nucleic acids research 46.21 (2018): 11202-11213.

Pubmed: 30137413

DOI: 10.1093/nar/gky754

Research Highlights

They concentrate on DYRK1A's properties, regulation, and functional relevance in various human disorders, which brings us to a summary of upcoming studies on this protein with exciting therapeutic potential.
Deboever, Estelle, et al. "The omnipresence of DYRK1A in human diseases." International journal of molecular sciences 23.16 (2022): 9355.
Pubmed: 36012629 DOI: 10.3390/ijms23169355

The importance of DYRK1A in a variety of illnesses is further supported by the significant efforts being made in drug development to create strong and specific DYRK1A inhibitors. Recently, a number of classes of DYRK1A inhibitors have been identified, and some of these compounds show promise for the development of DYRK1A inhibitors as medications for DYRK1A-dependent illnesses.
Abbassi, Ramzi, et al. "DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications." Pharmacology & therapeutics 151 (2015): 87-98.
Pubmed: 25795597 DOI: 10.1016/j.pharmthera.2015.03.004