mProX™ Human CSNK2A2 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1089	Magic™ Human CK2α2/β(CSNK2A2/B) in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

CSNK2A2

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

MDA-MB-231; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Infectious Research; Reproductive Research

Related Diseases

Theileriasis and Spermatogenic Failure 6. Among its related pathways are Gene expression (Transcription) and Selective autophagy

Gene ID

1459

UniProt ID

P19784

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Because it encodes the catalytic α subunit of casein kinase 2, CSNK2A2 plays a part in controlling the phosphorylation and movement of aged proteasomes (CK2α). Acidic proteins are phosphorylated by casein kinase 2, a serine/threonine protein kinase. By phosphorylating CTNNB1 and the transcription factor LEF1, it can control Wnt signaling. As a result, it plays a role in several essential physiological functions, including the advancement of the cell cycle, the suppression of apoptosis, the repair of DNA damage, differentiation, transcription, and viral infection. The gene CSNK2A2 is linked to a number of cancers, including glioblastoma multiforme, colorectal, breast, and ovarian cancers. It is also linked to certain illnesses, including diabetes, theileriasis in cattle, and distal muscular dystrophy in mice with anterior tibial start. The customized CSNK2A2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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The CSNK2A2 cell line's ease of use and reproducibility have significantly expedited our experiments. Dec 06 2022

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The consistent performance and reproducibility of CSNK2A2 cell line have significantly boosted the quality of our data. Oct 30 2022

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 CK2 Expression Is Elevated in Human Breast Cancer Cells Compared to Normal Tissue.

By MDA-MB-231 and MCF-7 human breast cancer cells, MCF-10A immortalized human breast epithelium cells, and perfused, normal murine tissues like the brain, heart, liver, lung, spleen, and uterus, the levels of CK2α, α', and β were measured by immunoblotting.

Ref: Gray, G. Kenneth, et al. "Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells." Oncotarget 5.15 (2014): 6484.

Pubmed: 25153725

DOI: 10.18632/oncotarget.2248

Research Highlights

This work revealed three new loci linked to SLE and shown how SLE GWAS results can be used to reposition medications.
Wang, Yong-Fei, et al. "Identification of ST3AGL4, MFHAS1, CSNK2A2 and CD226 as loci associated with systemic lupus erythematosus (SLE) and evaluation of SLE genetics in drug repositioning." Annals of the rheumatic diseases 77.7 (2018): 1078-1084.
Pubmed: 29625966 DOI: 10.1136/annrheumdis-2018-213093

A serine-threonine kinase that is widely expressed in eukaryotic cells and involved in a number of cellular functions is called casein kinase 2 (CK2).
Nakashima, Mitsuko, et al. "Identification of de novo CSNK2A1 and CSNK2B variants in cases of global developmental delay with seizures." Journal of human genetics 64.4 (2019): 313-322.
Pubmed: 30655572 DOI: 10.1038/s10038-018-0559-z