mProX™ Human CSNK2A1 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1088	Magic™ Human CK2α1/β(CSNK2A1/B) in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

CSNK2A1

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

MPNST; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

CNS Research; Cancer Research

Related Diseases

Okur-Chung Neurodevelopmental Syndrome and Prostate Stromal Sarcoma. Among its related pathways are Gene expression (Transcription) and Selective autophagy

Gene ID

1457

UniProt ID

P68400

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The human CSNK2A1 gene encodes the enzyme casein kinase II subunit alpha. A serine/threonine protein kinase called casein kinase II phosphorylates acidic proteins like casein. The alpha, alpha-prime, and two beta subunits make up the tetramer of the kinase. While the beta subunits go through autophosphorylation, the alpha subunits are the ones with catalytic activity. The alpha subunit is represented by the protein that this gene encodes. A related transcribed pseudogene is located on chromosome 11, despite the fact that this gene is located on chromosome 20. For this gene, three transcript variants that encode two distinct proteins have been discovered. The customized CSNK2A1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Ashley

For CSNK2A1 drug discovery, this is a good choice. May 18 2022

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chat Thomas

The cell line is ideal for helping to detect CSNK2A1. Apr 02 2020

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 CK2 is overexpressed in MPNSTs

QPCR analysis showed that MPNST cell lines had greater levels of CK2α mRNA expression (2-5) as compared to control normal human Schwann cells (NHSCs). Every MPNST cell line exhibited an overexpression of the CK2α protein.

Ref: Kendall, Jed J., et al. "CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin." Oncotarget 7.33 (2016): 53191.

Pubmed: 27448963

DOI: 10.18632/oncotarget.10668

Research Highlights

These results indicated that CSNK2A1 may be a potential prognostic and/or therapeutic target in GC and that it plays significant oncogenic functions in GC invasion via EMT and the PI3K-Akt-mTOR signaling pathway.
Jiang, Chao, et al. "CSNK2A1 promotes gastric cancer invasion through the PI3K-Akt-mTOR signaling pathway." Cancer Management and Research (2019): 10135-10143.
Pubmed: 31819646 DOI: 10.2147/CMAR.S222620

This study shows that SIRT6 and CSNK2A1 are markers of a poor prognosis for breast carcinomas and that the phosphorylation of SIRT6 by CSNK2A1 may play a role in the development of breast carcinomas.
Bae, Jun Sang, et al. "CK2α/CSNK2A1 phosphorylates SIRT6 and is involved in the progression of breast carcinoma and predicts shorter survival of diagnosed patients." The American Journal of Pathology 186.12 (2016): 3297-3315.
Pubmed: 27746184 DOI: 10.1016/j.ajpath.2016.08.007