mProX™ Human CSNK1G3 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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InquiryBased on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.
| Sub Cat | Product Name | Target Protein Species | Host Cell Type | Assay Types | Inquiry | Datasheet |
|---|---|---|---|---|---|---|
| S01YF-1122-KX1085 | Magic™ Human CK1γ3(CSNK1G3) in Vitro Assay | Human | Kinase Assay |
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Published Data
Fig.1 circRNAs regulate the expression of interferon signals and pro-inflammatory cytokines in tumor cells.
Examples of the circFISH test used to identify the circular and linear isoforms of Csnk1g3 and Ankib1. The circles overlayed in the rightmost panels indicate the detection of a circRNA (green circle) or linRNA (yellow or red circle).
Ref: Piras, Roberta, et al. "circCsnk1g3-and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment." Nature Communications 13.1 (2022): 7243.
Pubmed: 36433954
DOI: 10.1038/s41467-022-34872-8
Research Highlights
In the majority of eukaryotic cells, serine/threonine kinases like those in the casein kinase 1 family regulate signal transduction. Particularly, CK1 isoforms are implicated in DNA transcription, nucleocytoplasmic transfer of transcription factors, circadian rhythms, Wnt signaling, and DNA repair.
Son, Hyun Ji, et al. "Intratumoral heterogeneity of CSNK1G3 mutations, a casein kinase 1, in colon cancers." Pathology, research and practice 216.5 (2020): 152936.
Pubmed:
32241596
DOI:
10.1016/j.prp.2020.152936
CircRNAs are found in cancer patients' and healthy people's plasma, cell-free saliva, urine, and proteins. They can be found free, bound to proteins, or coupled with exosomes, underscoring their significance as non-invasive indicators.
Nigam, Shivansh, Nishat Manzar, and Bushra Ateeq. "Implications of the circular RNAs in localized prostate cancer." Annals of Translational Medicine 7.Suppl 6 (2019).
Pubmed:
31656774
DOI:
10.21037/atm.2019.07.23
