mProX™ Human CSNK1G1 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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InquiryBased on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.
| Sub Cat | Product Name | Target Protein Species | Host Cell Type | Assay Types | Inquiry | Datasheet |
|---|---|---|---|---|---|---|
| S01YF-1122-KX1083 | Magic™ Human CK1γ1(CSNK1G1) in Vitro Assay | Human | Kinase Assay |
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Published Data
Fig.1 circCSNK1G1 is upregulated in OA-affected cartilage.
CircSNK1G1 expression was found in the cartilage tissues of OA patients, which helps to elucidate the function of circRNAs in the disease. In contrast to normal cartilage tissue, OA-affected cartilage showed a clear upregulation of circCSNK1G1 expression. These findings suggest that circCSNK1G1 might have a regulatory function in the development of OA.
Ref: Xiao, Jianwei, et al. "Circular RNA CSNK1G1 promotes the progression of osteoarthritis by targeting the miR‑4428/FUT2 axis Retraction in/10.3892/ijmm. 2022.5080." International journal of molecular medicine 47.1 (2021): 232-242.
Pubmed: 34981817
DOI: 10.3892/ijmm.2022.5080
Research Highlights
The protein encoded by CSNK1G1, casein kinase 1 gamma-1 isoform, is involved in cell development and morphogenesis. This protein is widely expressed in a variety of tissues, including the brain, where it contributes to synaptic transmission and controls the phosphorylation of N-methyl-D-aspartate receptors.
Gold, Nina B., et al. "Heterozygous de novo variants in CSNK1G1 are associated with syndromic developmental delay and autism spectrum disorder." Clinical Genetics 98.6 (2020): 571-576.
Pubmed:
33009664
DOI:
10.1111/cge.13851
Through modulating the miR-28-5p/LDHA pathway, Circ-CSNK1G1 stimulates cell migration, invasion, proliferation, and glycolysis metabolism during TNBC formation.
Zan, Xiaochen, et al. "Circ-CSNK1G1 promotes cell proliferation, migration, invasion and glycolysis metabolism during triple-negative breast cancer progression by modulating the miR-28-5p/LDHA pathway." Reproductive Biology and Endocrinology 20.1 (2022): 1-14.
Pubmed:
36109751
DOI:
10.1186/s12958-022-00998-z
