mProX™ Human CSNK1D Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1086	Magic™ Human CK1δ(CSNK1D) in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

CSNK1D

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

MDA-MB-231; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

CNS Research; Reproductive Research

Related Diseases

Advanced Sleep Phase Syndrome, Familial, 2 and Advanced Sleep Phase Syndrome. Among its related pathways are Loss of Nlp from mitotic centrosomes and rRNA processing in the nucleus and cytosol

Gene ID

1453

UniProt ID

P48730

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The human enzyme casein kinase I isoform delta, commonly referred to as CKI-delta or CK1δ, is encoded by the CSNK1D gene, located on chromosome 17 (17q25.3). It belongs to the family of serine/threonine specific eukaryotic protein kinases known as CK1 (previously known as casein kinase 1), which includes seven different isoforms (CK1α, γ1-3, δ, ε) and several post-transcriptionally processed splice variants (transcription variants, TVs) in mammals. In the meantime, analogous proteins of CK1δ have been isolated from plants, algae, yeast, basidiomycetes, and protozoa. The customized CSNK1D stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Linda

The results have been consistent and reliable, providing crucial insights into CSNK1D research. Mar 08 2020

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chat Shirley

The CSNK1D cell line has streamlined my assays and allowed me to obtain accurate data. Jul 14 2021

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 Effect of CSNK1D inactivation on the migration of the triple negative breast cancer cell line MDA-MB-231.

A wound healing experiment was used to assess representative images of the cell migratory capacity of shNT and shCSNK1D throughout a 24-hour period.

Ref: Bar, Isabelle, et al. "Silencing of casein kinase 1 delta reduces migration and metastasis of triple negative breast cancer cells." Oncotarget 9.56 (2018): 30821.

Pubmed: 30112110

DOI: 10.18632/oncotarget.25738

Research Highlights

While AFP is not as good at predicting the prognosis of HCC patients, CSNK1D is an independent factor that influences the prognosis of HCC patients and may be developed as a possible therapeutic target for HCC.
Zhang, Huiting, et al. "Upregulation of the Stress-Induced Protein Kinase CK1 (CSNK1D) Protein is Associated with a Poor Prognosis in Hepatocellular Carcinoma." Genetic testing and molecular biomarkers 25.7 (2021): 504-514.
Pubmed: 34280005 DOI: 10.1089/gtmb.2020.0093

According to these findings, CSNK1D may have an impact on the stemness and invasiveness of GSCs, which may make it a viable target for treatment in GBM patients. It also appears to be connected with the prognosis of GBM.
Liu, Yixiong, et al. "CSNK1D is associated with stemness and invasiveness in glioblastoma." Pathology-Research and Practice 240 (2022): 154187.
Pubmed: 36327821 DOI: 10.1016/j.prp.2022.154187