mProX™ Human CLDN4 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
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Published Data
Fig.1 In the claudin-4-overexpressing clones of SNU638 and MKN1 cells, the expression of Claudin-4 is observed.
Ref: Kwon, Mi Jeong, et al. "Claudin-4 overexpression is associated with epigenetic derepression in gastric carcinoma." Laboratory investigation 91.11 (2011): 1652-1667.
Pubmed: 21844869
DOI: 10.1038/labinvest.2011.117
Research Highlights
Wang, Xinxian. et al. "Long non-coding RNA LOC103222771 promotes infection of porcine reproductive and respiratory syndrome virus in Marc-145 cells by downregulating Claudin-4." Veterinary microbiology, 2023.
Porcine reproductive and respiratory syndrome (PRRS) is caused by a viral infection (PRRSV) and has significant economic impact on the swine industry. Effective control of PRRS is challenging and requires a deeper understanding of the role of long non-coding RNAs (lncRNAs) as key regulators of viral infections and immune responses. A study using Marc-145 cells and porcine alveolar macrophages (PAMs) found that PRRSV infection increased the expression of lncRNA LOC103222771 which is primarily located in the cytoplasm. Inhibition of LOC103222771 resulted in decreased PRRSV infection in Marc-145 cells. Further analysis identified an interaction between LOC103222771 and Claudin-4 (CLDN4), an important component of tight junctions that regulate movement of molecules between cells. Downregulation of CLDN4 was also found to enhance PRRSV infection. These results suggest that the LOC103222771/CLDN4 axis may be a novel mechanism involved in PRRSV pathogenesis and could be a potential therapeutic target for controlling PRRSV infection.
Wang, Xinxian. et al. "Long non-coding RNA LOC103222771 promotes infection of porcine reproductive and respiratory syndrome virus in Marc-145 cells by downregulating Claudin-4." Veterinary microbiology, 2023.
Pubmed:
37857013
DOI:
10.1016/j.vetmic.2023.109890
Okamoto, Ema. et al. "Increase in paracellular leakage of amino acids mediated by aging-induced reduction of claudin-4 expression." The Journal of nutrition, 2023.
The role of Claudins (CLDNs), which serve as major components of tight junctions, is to regulate the paracellular permeabilities of mineral ions and wastes. Intestinal epithelial cells are responsible for controlling the absorption of nutrients such as glucose and amino acids (AAs). Despite their importance, the exact function of CLDNs is still not completely understood.
Okamoto, Ema. et al. "Increase in paracellular leakage of amino acids mediated by aging-induced reduction of claudin-4 expression." The Journal of nutrition, 2023.
Pubmed:
37806357
DOI:
10.1016/j.tjnut.2023.09.026
