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    mProX™ Human CLDN4 Stable Cell Line

    [CAT#: S01YF-1023-PY264]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;SNU638;MKN1
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Cancer Research
    Related Diseases
    Ovarian Cystadenoma; Williams-Beuren Syndrome
    Gene ID
    Human:1364
    UniProt ID
    Human:O14493

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CLDN4, also known as Claudin-4, has various applications in different fields. In the field of lung development and injury repair, CLDN4 is shown to restrict alveolar type 2 (AT2) cell plasticity, which has implications in lung regeneration and cancer. In the context of porcine reproductive and respiratory syndrome virus (PRRSV) infection, CLDN4 is downregulated by a long non-coding RNA (lncRNA) called LOC103222771, which promotes PRRSV infection in cells. CLDN4 is also involved in the regulation of paracellular permeability of amino acids (AAs) in the intestine, and its expression is reduced with aging, leading to an increase in paracellular leakage of AAs. Additionally, CLDN4 is part of a complex network of claudins that regulate epithelial barrier function in the gastrointestinal tract. Finally, a strain of Lactobacillus plantarum called HY7718, which has superior storage stability, has been found to restore the expression of CLDN4 and other tight junction proteins, suggesting its potential as a probiotic for intestinal health.

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    FAQ

    chat Morgan Smith (Verified Customer)

    What is the role of CLDN4 in colorectal cancer? Apr 30 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Clostridium perfringens enterotoxin may enhance the malignant transformation of colorectal cancer via YAP activation, implicating CLDN4 in the progression of colorectal cancer. Apr 30 2020

    chat Jordan Garcia (Verified Customer)

    How does CLDN4 expression influence renal cell carcinoma? Sep 10 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Nuclear localization of CLDN4 in renal cell carcinoma may contribute to the malignancy of the cancer, suggesting its potential as a therapeutic target. Sep 10 2020

    Related Products by Target
    • Magic™ Human CLDN4 CHO-K1 Cell Line (CAT#: S01YF-0123-KX78)
    • Magic™ Human CLDN4 HEK293T Cell Line (CAT#: S01YF-0123-KX79)
    • mProX™ Human CLDN4 Stable Cell Line (CAT#: S01YF-1023-PY264)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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