Recommended
product-img
  • Products
  • Discover MP Targets
  • Discover Research Areas
  • mProX™ Human CLDN3 Stable Cell Line

    [CAT#: S01YF-1023-PY263]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

    Datasheet MSDS Request COA

    Certificate of Analysis Lookup
    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
    Lot Number

    Made to Order Inquiry

    Inquiry
    Host Cell Type:
    Membrane Protein Engineering:
    Fluorescent Marker:
    Resistance:
    Deliverable:

    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;Huh-7;HepG2
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Cancer Research
    Related Diseases
    Papillary Carcinoma; Williams-Beuren Syndrome
    Gene ID
    Human:1365
    UniProt ID
    Human:O15551

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CLDN3, a member of the claudin family of tight junction proteins, has been studied in various contexts. One study investigated the impact of chronic exposure to arsenate through drinking water on the intestinal barrier and found that chronic exposure to As(V) affects the expression of CLDN3, among other proteins, leading to increased paracellular permeability and endotoxemia. Another study focused on the role of CLDN3 in regulating epithelial tight junction architecture. It was found that CLDN23, in association with CLDN3 and CLDN4, reshapes tight junctions and regulates barrier function. Additionally, CLDN3 has been studied in the context of fructans, where it was found that specific fructans can protect the expression of CLDN3 and other tight junction genes, contributing to gut homeostasis. Lastly, CLDN3 was examined in pulmonary adenoid cystic carcinoma and mucoepidermoid carcinoma, where overexpression of CLDN3 was observed. These studies highlight the diverse applications of CLDN3 in understanding intestinal barrier function, tight junction architecture, and disease pathology.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human CLDN3 Stable Cell Line (S01YF-1023-PY263). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Skyler Johnson (Verified Customer)

    What is the significance of CLDN3 overexpression in ovarian cancer? Apr 22 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Overexpression of CLDN3 in ovarian cancer promotes cellular viability, migration, and invasion, suggesting that targeting CLDN3 could provide new therapeutic opportunities. Apr 22 2023

    chat Jordan Williams (Verified Customer)

    How does CLDN3 expression affect breast cancer? May 04 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Loss of CLDN3 expression in breast cancer cells may play a role in invasion and metastasis, indicating its potential as a biomarker for cancer progression. May 04 2021
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
    Send Inquiry Send Inquiry
    Inquiry Basket
    compare

    Go to compare