mProX™ Human CLDN3 Stable Cell Line

Domene, Adri√°n. et al. "Impact of Chronic Exposure to Arsenate through Drinking Water on the Intestinal Barrier." Chemical research in toxicology, 2023.
Chronic exposure to inorganic arsenic, specifically As(III) and As(V), has been found to increase the risk of certain types of cancer and other non-carcinogenic conditions in a significant portion of the population. While the primary route of exposure is through oral ingestion, it has been noted that children may be at a heightened risk due to their vulnerability. This issue affects millions of individuals worldwide.
Domene, Adri√°n. et al. "Impact of Chronic Exposure to Arsenate through Drinking Water on the Intestinal Barrier." Chemical research in toxicology, 2023.
Pubmed: 37819996   DOI: 10.1021/acs.chemrestox.3c00201

Raya-Sandino, Arturo. et al. "Claudin-23 reshapes epithelial tight junction architecture to regulate barrier function." Nature communications, 2023.
It is shown that CLDN23 is highly expressed in luminal intestinal epithelial cells and plays a crucial role in strengthening the barrier. The study also reveals that CLDN23 interacts with CLDN3 and CLDN4 to regulate paracellular ion and macromolecule permeability. Computational modeling suggests that CLDN23 forms heteromeric and heterotypic complexes with unique pore architecture and overall net charge. These findings shed light on the organization of tight junctions and propose a model wherein different claudins form distinct complexes to modify epithelial barrier function.
Raya-Sandino, Arturo. et al. "Claudin-23 reshapes epithelial tight junction architecture to regulate barrier function." Nature communications, 2023.
Pubmed: 37798277   DOI: 10.1038/s41467-023-41999-9