mProX™ Human CIT Stable Cell Line
[CAT#: S01YF-1123-KX208]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
CIT
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
HeLa; CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Reproductive Research
Related Diseases
Microcephaly 17, Primary, Autosomal Recessive and Primary Autosomal Recessive Microcephaly. Among its related pathways are Signaling by Rho GTPases and RHOC GTPase cycle
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The CIT gene in humans codes for the enzyme citron Rho-interacting kinase. Its overexpression in HeLa cells caused the host cells to become multinucleated, and its removal hinders the preservation of the midbody. Citron-K is expressed during the process of neurogenesis and is involved in the division of neural progenitor cells. In both rats and mice, recessive mutations in Citron-K result in severe microcephaly. Neurogenic cytokinesis abnormalities are caused by loss of Citron-K expression in both humans and animals. Similar to this, RNAi suppression of Citron-K in Drosophila causes cellular abscission to fail. The condition microlissencephaly is linked to CIT. The customized CIT stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Lisa
The CIT overexpression cell line has played a pivotal role in our journey of discovery.
Dec 27 2022
Verified Customer
Michael
I've used the CIT cell line in multiple assays, and each time, it has exceeded my expectations.
Nov 24 2021
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
