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    mProX™ Human CEACAM5 Stable Cell Line

    [CAT#: S01YF-1023-PY262]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;FaDu;SCC15
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Cancer Research
    Related Diseases
    Bile Duct Cancer; Rectum Cancer
    Gene ID
    Human:1048
    UniProt ID
    Human:P06731

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CEACAM5, also known as carcinoembryonic antigen-related cell adhesion molecule 5, has been implicated in various applications. In colorectal cancer, CD44 isoform 4, which is predominantly expressed in patients, is associated with poor outcome, epithelial-mesenchymal transition (EMT), and decreased oxidative phosphorylation. Knockdown of CD44 isoforms impairs tumor formation and metastasis in xenograft models. CEACAM5 is downregulated upon CD44 knockdown, leading to increased tumor angiogenesis and reduced HIF-1α expression. In pancreatic cystic neoplasms, CEACAM5 is identified as a potential diagnostic biomarker for distinguishing malignant PCNs. A highly sensitive immunoassay based on pentameric Nbs targeting CEACAM5 has been developed for accurate detection. Furthermore, CEACAM5 is identified as one of the key genes associated with the severity classification of asthma, potentially providing new insights for prediction and targeted therapy.

    Protocols

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    FAQ

    chat Jordan Miller (Verified Customer)

    What is the role of CEACAM5 in gastric epithelial cells? Oct 14 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CEACAM5 interacts with Helicobacter pylori adhesion protein HopQ, potentially inducing gastric ulcers and cancers by transferring CagA oncoprotein or activating T4SS to initiate inflammatory reactions. Oct 14 2023

    chat Skyler Brown (Verified Customer)

    How does CEACAM5 influence the progression of lung cancer? Dec 04 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CEACAM5-targeted therapies, such as tusamitamab ravtansine, have shown favorable safety profiles and efficacy in treating non-squamous non-small cell lung cancer expressing CEACAM5, suggesting its potential as a therapeutic target. Dec 04 2022

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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