mProX™ Human CDK13 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1061	Magic™ Human CDK13/CycK in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

CDK13

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

HCT116; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Cardiovascular Research; Reproductive Research

Related Diseases

Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder and Autism Spectrum Disorder. Among its related pathways are Gene expression (Transcription) and Innate Immune System

Gene ID

8621

UniProt ID

Q14004

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The CDK13 gene in humans codes for the enzyme cyclin dependent kinase 13. This gene codes for a protein that belongs to the family of serine/threonine protein kinases that are dependent on cyclins. This family's members are widely known for playing crucial roles as master switches in the regulation of the cell cycle. Connections between cell proliferation, differentiation, and apoptosis can be found because some cell cycle regulatory kinases have the ability to phosphorylate proteins that are crucial for these processes. This family of proteins may also be involved in processes unrelated to the cell cycle, like the dynamics of the neurocytoskeleton. It is yet unknown what precisely this protein does. It is widely expressed in a variety of tissues and possesses atypically big N- and C-termini. The customized CDK13 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Ashley

I have purchased this CDK13 cell line and all producing reliable results. May 26 2023

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chat Shirley

The mouse CDK13 cell line is an excellent candidate for use in in vitro assays, and I highly recommend it to anyone working in this field. Sep 23 2022

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 Knockdown of Cdk12 or Cdk13 Exhibits Different Gene Expression Profiles.

Expression microarray analysis was used to identify the genes that were differently regulated following siRNA knockdown of Cdk12 (siCdk12) or Cdk13 (siCdk13) in HCT116 cells. Plotting gene relative average expression levels against fold change is done.

Ref: Greifenberg, Ann Katrin, et al. "Structural and functional analysis of the Cdk13/Cyclin K complex." Cell reports 14.2 (2016): 320-331.

Pubmed: 26748711

DOI: 10.1016/j.celrep.2015.12.025

Research Highlights

The finding that CDK12 functions as a tumor suppressor, particularly in specific cases of prostate and ovarian cancer, points to a significant area of future research that will be important for medicine.
Greenleaf, Arno L. "Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium." Transcription 10.2 (2019): 91-110.
Pubmed: 30319007 DOI: 10.1080/21541264.2018.1535211

According to these studies, there is a significant overlap between CDK12 and CDK13, and they are both essential regulators of transcription elongation and global POLII processivity.
Fan, Zheng, et al. "CDK13 cooperates with CDK12 to control global RNA polymerase II processivity." Science advances 6.18 (2020): eaaz5041.
Pubmed: 32917631 DOI: 10.1126/sciadv.aaz5041