mProX™ Human CDC42BPB Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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InquiryBased on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.
| Sub Cat | Product Name | Target Protein Species | Host Cell Type | Assay Types | Inquiry | Datasheet |
|---|---|---|---|---|---|---|
| S01YF-1122-KX1229 | Magic™ Human MRCKβ(CDC42BPB) in Vitro Assay | Human | Kinase Assay |
Product Information
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Jordan Davis (Verified Customer)
Patrick Liam (Creative Biolabs Scientific Support)
Taylor Davis (Verified Customer)
Patrick Liam (Creative Biolabs Scientific Support)
Published Data
Fig.1 Inhibition of cell proliferation was achieved through the knockdown of CDC42BPA and CDC42BPB.
In BT549 cells, knockdown of CDC42BPA and CDC42BPB was carried out, followed by a 5-day culture period and subsequent staining with crystal violet. The graph displays the relative cell density, based on data from three independent experiments.
Ref: Yamaguchi, Hirohito, et al. "MRCK as a Potential Target for Claudin-Low Subtype of Breast Cancer." Int. J. Biol. Sci 1 (2024): 1.
Pubmed: NA
DOI: 10.7150/ijbs.88285
Research Highlights
Tang, Qiong. et al. "A Case Report of Cardiofaciocutaneous Syndrome with MAP2K1 Pathogenic Variant." Pharmacogenomics and personalized medicine, 2023.
Cardiofaciocutaneous syndrome (CFCS) is an extremely rare disorder characterized by craniofacial dysmorphism, cardiac abnormalities, ectodermal abnormalities, psychomotor delay, intellectual disability, and short stature. Despite its rarity, about 300 cases have been reported in the literature. This study presents a case of CFCS in a patient who lacked the typical heart malformations but displayed craniofacial features, skin abnormalities, intellectual disability, and short stature. Genetic testing identified three potentially harmful variants, including a variant in the BRAF gene and two in the MAP2K1 gene. Further research is needed to understand the underlying mechanisms and to develop targeted treatments for CFCS.
Tang, Qiong. et al. "A Case Report of Cardiofaciocutaneous Syndrome with MAP2K1 Pathogenic Variant." Pharmacogenomics and personalized medicine, 2023.
Pubmed:
37705935
DOI:
10.2147/PGPM.S411964
Wu, Qinhang. et al. "Zhuidu Formula suppresses the migratory and invasive properties of triple-negative breast cancer cells via dual signaling pathways of RhoA/ROCK and CDC42/MRCK." Journal of ethnopharmacology, 2023.
The Zhuidu Formula (ZDF) is a combination of three active ingredients found in Tripterygium wilfordii Hook. F, dried toad skin, and Taxus wallichiana var. chinensis (Pilg) Florin, namely triptolide, cinobufagin, and paclitaxel. Modern studies have displayed these natural compounds' ability to hinder DNA synthesis, trigger apoptosis in tumor cells, and disrupt the tubulin balance, making them effective against tumor growth. Despite this, the mechanism through which they inhibit metastasis in triple-negative breast cancer (TNBC) remains unclear.
Wu, Qinhang. et al. "Zhuidu Formula suppresses the migratory and invasive properties of triple-negative breast cancer cells via dual signaling pathways of RhoA/ROCK and CDC42/MRCK." Journal of ethnopharmacology, 2023.
Pubmed:
37196814
DOI:
10.1016/j.jep.2023.116644
