mProX™ Human CDC42BPB Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

CDC42BPB (Cell Division Cycle 42 Binding Protein Beta) has been implicated in various biological processes and diseases. One case report discusses the presence of potentially harmful variants in the CDC42BPB gene in a patient with Cardiofaciocutaneous Syndrome (CFCS), expanding our understanding of the symptom spectrum of the disease. Additionally, a study demonstrates that the inhibition of CDC42/MRCK signaling pathways by the Zhuidu Formula (ZDF) can suppress the migratory and invasive properties of triple-negative breast cancer cells. Another study identifies CDC42BPB as a candidate modifier gene for the penetrance of Leber's Hereditary Optic Neuropathy (LHON), suggesting its potential role in influencing the development of this disease. Finally, a study examining the effects of Cdc42bpb deletion in mice shows that heterozygous deletion of the gene does not significantly alter ethanol-related behaviors, but it is associated with mild hyperactivity and urogenital deformities in mice. Overall, CDC42BPB has been implicated in cellular migration, cancer metastasis, disease penetrance, and normal mouse behavior.