mProX™ Human CD36 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

CD36 is a protein that plays a role in various physiological processes. In the context of pulmonary arterial hypertension (PAH), CD36 is involved in metabolic signaling in right ventricle (RV) cardiomyocytes. Increased circulating leptin, which is associated with metabolic syndrome, can influence metabolic changes in RV cardiomyocytes via the CD36 receptor. Additionally, CD36 may alter lipid-dependent RV metabolism in combination with metformin in a mutation-specific manner. CD36 is also implicated in the maturation of lipid metabolism in the fetal and newborn sheep heart, as its gene expression progressively increases during the perinatal period. In the context of cancer, CD36 is involved in inhibiting cell proliferation in an inflammatory microenvironment by suppressing glycolysis and lipid metabolism. Furthermore, CD36 is linked to cholesterol deficiency in autism, as valproic acid exposure reduces CD36 protein levels in human microglial cells and neuroblastoma cells. Lastly, CD36 is a target for therapeutic efficacy in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), as mitochondria-targeted esculetin (Mito-Esc) administration regulates CD36 levels and improves lipid profile and glucose homeostasis. Overall, CD36 has diverse applications in various physiological and pathological conditions.