mProX™ Human CD28 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

CD28 is a protein that plays a role in various applications. In the context of graft-versus-host disease (GVHD), CD28 is involved in sustaining T cell responses in target tissues, such as the liver and intestine. Its loss can lead to aberrant expression of PD-1 in T cells, decreased numbers of tissue-infiltrating PD-1+ T cells, and impaired maintenance of progenitor-like T cells. However, PD-1 blockade can restore the capacity of CD28-deficient T cells to mediate GVHD. CD28 is also required for protecting CD8+ T cells from PD-1 pathway-mediated suppression during GVHD. In addition, CD28 is important for the function of CAR-T cells, a type of immunotherapy for cancer. It is involved in the expansion, activation, and cytotoxicity of CAR-T cells. CD28 signaling is also associated with the immune response to vaccines. In a study on turbot fish, CD28 was found to be differentially expressed in kidney tissue after vaccination with an inactivated bivalent vaccine. Furthermore, CD28 is implicated in the interplay between SARS-CoV-2 and HIV. In individuals co-infected with these viruses, CD28 expression on T cells is dysregulated, leading to immune activation and altered T cell exhaustion. Overall, CD28 has important roles in immune responses, immunotherapy, vaccine responses, and viral infections.