mProX™ Human CAMK2B Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1051	Magic™ Human CaMK2β(CAMK2B) in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

CAMK2B

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

SK-RC-39; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Reproductive Research

Related Diseases

Intellectual Developmental Disorder, Autosomal Dominant 54 and Autosomal Dominant Non-Syndromic Intellectual Disability. Among its related pathways are Calmodulin induced events and Signaling downstream of RAS mutants

Gene ID

816

UniProt ID

Q13554

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The human CAMK2B gene encodes the enzyme calcium/calmodulin-dependent protein kinase type II beta chain. The enzyme is a member of the Ca2+/calmodulin-dependent protein kinase subfamily and the serine/threonine protein kinase family. Multiple facets of glutamatergic synapses' plasticity depend on calcium signaling. The enzyme in mammalian cells is made up of four distinct chains: delta, gamma, beta, and alpha. A beta chain is the gene's product. various isoforms of this chain may interact with calmodulin in various ways and have different cellular localizations. For this gene, eight transcript variants that encode eight different isoforms have been found. The customized CAMK2B stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Deborah

I recently had the opportunity to try the CAMK2B cell line from Creative Biolabs, and I am quite impressed. The product arrived promptly, and the packaging was secure. The provided instructions were clear and easy to follow. Aug 20 2022

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chat Amanda

I can't speak highly enough about the human CAMK2B cell line. It has exceeded my expectations in terms of performance and has become an invaluable asset in our lab. Mar 07 2020

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 Upregulation of CAMK2B is associated with decreases in proliferation and fibroblast infiltration.

With lentiviral transfection, CAMK2B was either overexpressed or subjected to short-hairpin (sh) RNA-mediated silencing in SK-RC-39 cells. As demonstrated by migration experiments, migration is improved following CAMK2B silencing, although less CAMK2B overexpressing cells traverse the basement membrane than SK-RC-39 control cells.

Ref: Jia, Qingan, et al. "Anti-tumor role of CAMK2B in remodeling the stromal microenvironment and inhibiting proliferation in papillary renal cell carcinoma." Frontiers in oncology 12 (2022): 740051.

Pubmed: 35127542

DOI: 10.3389/fonc.2022.740051

Research Highlights

This paper illustrates the intrafamilial heterogeneity of CAMK2B mutant expression and broadens the clinical phenotypic spectrum of the disease.
Heiman, Paige, Sarah Drewes, and Lina Ghaloul-Gonzalez. "A familial case of CAMK2B mutation with variable expressivity." SAGE Open Medical Case Reports 9 (2021): 2050313X21990982.
Pubmed: 33796307 DOI: 10.1177/2050313X21990982

The significance of CaMKIIα and CaMKIIβ, along with their autoinhibitory control, in human brain function is underscored by these observations, which also point to the potential pathological basis of the amplification of A-type K+ currents.
Akita, Tenpei, et al. "De novo variants in CAMK 2A and CAMK 2B cause neurodevelopmental disorders." Annals of clinical and translational neurology 5.3 (2018): 280-296.