mProX™ Human CAMK1D Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1049	Magic™ Human CaMK1δ(CAMK1D) in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

CAMK1D

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

U251; A172; LN229; U87; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

CNS Research; Reproductive Research

Related Diseases

Ceroid Lipofuscinosis, Neuronal, 6A and Wolfram Syndrome 1. Among its related pathways are Prolactin Signaling and B Cell Receptor Signaling Pathway

Gene ID

57118

UniProt ID

Q8IU85

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The human protein known as calcium/calmodulin-dependent protein kinase ID is encoded by the CAMK1D gene located on chromosome 10. A member of the serine/threonine kinase 1 subfamily of Ca2+/calmodulin-dependent protein kinases is encoded by this gene. The chemokine signal transduction pathway may be used by the encoded protein to regulate granulocyte function. There have been reported variants of this gene's alternative splicing transcript that encode distinct isoforms. The customized CAMK1D stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Robert

The human CAMK1D cell line worked as advertised and was a cost-effective alternative in our studies. We obtained consistent results, and the cell line showed good stability over extended periods. Jul 14 2023

chat Verified Customer

chat Jennifer

The CAMK1D KO cell line worked flawlessly, and the detailed protocols provided by the company made the whole process much easier. Mar 15 2022

chat Verified Customer

FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 CAMK1D level changes on the PI3K/AKT/mTOR pathway.

Western blot research revealed that in glioma cells, overexpression of CAMK1D reduced the ratios of p-Akt/Akt, p-mTOR/mTOR, and p-P70S6K/P70S6K and downregulated p-Akt, p-mTOR, and p-P70S6K.

Ref: Jin, Qianxu, et al. "CAMK1D inhibits glioma through the PI3K/AKT/mTOR signaling pathway." Frontiers in Oncology 12 (2022): 845036.

Pubmed: 35494053

DOI: 10.3389/fonc.2022.845036

Research Highlights

According to this study, CAMK1D controls glioma cell function through the PI3K/AKT/mTOR pathway. Ultimately, our results imply that CAMK1D functions as a novel target for glioma treatment development as well as a prognostic indicator.
Jin, Qianxu, et al. "CAMK1D inhibits glioma through the PI3K/AKT/mTOR signaling pathway." Frontiers in Oncology 12 (2022): 845036.
Pubmed: 35494053 DOI: 10.3389/fonc.2022.845036

Tumor immune resistance may have been facilitated by the quick suppression of the final apoptotic cascade by CAMK1D expression in anti-PD-L1-refractory tumors through T-cell identification.
Volpin, Valentina, et al. "CAMK1D Triggers Immune Resistance of Human Tumor Cells Refractory to Anti-PD-L1 Treatment." Cancer Immunology Research 8.9 (2020): 1163-1179.
Pubmed: 32665263 DOI: 10.1158/2326-6066.CIR-19-0608